Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.
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Kobayashi, T., Takaesu, G. & Yoshimura, A. Mal-function of TLRs by SOCS. Nat Immunol 7, 123–124 (2006). https://doi.org/10.1038/ni0206-123
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DOI: https://doi.org/10.1038/ni0206-123
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