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Recent discoveries highlight the skull bone marrow, linked to the CNS via osseous channels, as a key neuroimmune compartment. Here, the authors discuss the anatomy, functions and implications of this immune reservoir on CNS health and disease.
This paper characterizes two distinct philosophies underlying previous work on how Bayesian computations are linked to neural data, highlighting how different theories may be motivated by different tacit assumptions and thereby explain different data.
Despite diversity, equity and inclusion efforts, women remain underrepresented as academic leaders in neuroscience. In this Perspective, Bourke, Spanò and Schuman discuss current European initiatives and propose further actions to support women’s career progression in STEM.
Recent progress in astrocyte biology requires a more cohesive conceptual framework. This Perspective introduces a ‘contextual guidance’ paradigm in which astrocytes are key to adaptive modeling of neural circuits in response to state changes.
Oligodendrocyte precursor cells (OPCs) are mostly known for their ability to differentiate into myelinating oligodendrocytes. Here, the authors discuss the multiple functions of OPCs beyond their precursor cell function in the healthy and diseased CNS.
Genome-wide association studies for brain and behavioral traits have provided insights but also present challenges related to privacy and misuse. We discuss these ethical issues and how to mitigate potential negative consequences.