Colliding ribosome structures

Putting a leash on Hippo

  • Gayoung Seo
  • Wenqi Wang
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    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in a special issue.

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    • The Hippo pathway is a key regulator of tissue homeostasis, organ size and cancer. Identification of microcolin B and its analog molecules as Hippo pathway activators connects PtdIns4P-dependent lipid signaling with the Hippo pathway, suggesting potential targets for cancer therapy.

      • Gayoung Seo
      • Wenqi Wang
      News & Views
    • This Perspective discussed selective partitioning behaviors of biomolecules and small molecules and proposed that understanding the chemical properties that control their interactions within the condensates would promote drug development.

      • Henry R. Kilgore
      • Richard A. Young
      Perspective
    • Several venomous predators and pathogens use insulins to capture prey and to manipulate host physiology. This Review provides an overview of the discovery and potential biomedical application of these and other weaponized hormones found in nature.

      • Sophie Heiden Laugesen
      • Danny Hung-Chieh Chou
      • Helena Safavi-Hemami
      Review Article
    • Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.

      • Tatiana J. Rosales
      • Brian M. Baker
      News & Views
    • Carbon dioxide (CO2) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO2-dependent carboxylation on lysine residues of proteins.

      • R. Justin Grams
      • Ku-Lung Hsu
      News & Views

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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