Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or protein design offer opportunities to therapeutically target cellular processes that have long been thought of as undruggable. We report on the progress and the potential for transformative collaborations between fields discussed at the 2023 Bringing Chemistry to Medicine symposium at St. Jude Children’s Research Hospital.
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Deane, C.D., Fischer, M. & Shelat, A.A. Bringing chemistry to medicine to redefine the undruggable. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01598-1
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DOI: https://doi.org/10.1038/s41589-024-01598-1
