Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short half-life of peptides. A study now reports thioamide substitution in the peptide backbone as a strategy to enhance resistance to proteolysis and promote binding to the MHC I complex for T cell activation.
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Zacharias, M., Springer, S. Peptide vaccines get an OS update. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01608-2
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DOI: https://doi.org/10.1038/s41589-024-01608-2