Biomolecular tailoring

Check out our March 2018 issue focusing on chemical modifications of biomolecules

Latest Research

  • Article |

    The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.

    • Sean A. Newmister
    • , Shasha Li
    • , Marc Garcia-Borràs
    • , Jacob N. Sanders
    • , Song Yang
    • , Andrew N. Lowell
    • , Fengan Yu
    • , Janet L. Smith
    • , Robert M. Williams
    • , K. N. Houk
    •  & David H. Sherman
  • Article |

    Post-translational modification of residues in an intrinsically disordered region of Bcl-XL promotes interactions with its folded core and allosterically reduces affinity for proapoptotic BH3-domain-containing proteins, resulting in apoptosis.

    • Ariele Viacava Follis
    • , Fabien Llambi
    • , Halime Kalkavan
    • , Yong Yao
    • , Aaron H. Phillips
    • , Cheon-Gil Park
    • , Francesca M. Marassi
    • , Douglas R. Green
    •  & Richard W. Kriwacki
  • Article |

    The substrate-tolerant lanthipeptide synthetase ProcM enables the construction of a plasmid-encoded library of bicyclic lanthipeptides, from which an inhibitor of the p6–UEV protein–protein interaction is identified by a reverse two-hybrid screen.

    • Xiao Yang
    • , Katherine R. Lennard
    • , Chang He
    • , Mark C. Walker
    • , Andrew T. Ball
    • , Cyrielle Doigneaux
    • , Ali Tavassoli
    •  & Wilfred A. van der Donk
  • Article |

    Selective TRIM24 degradation is achieved by co-opting the VHL E3 ubiquitin ligase machinery. TRIM24 degradation outperforms bromodomain inhibition, with an enhanced antiproliferative effect in acute leukemia, a novel context of TRIM24 dependency.

    • Lara N. Gechijian
    • , Dennis L. Buckley
    • , Matthew A. Lawlor
    • , Jaime M. Reyes
    • , Joshiawa Paulk
    • , Christopher J. Ott
    • , Georg E. Winter
    • , Michael A. Erb
    • , Thomas G. Scott
    • , Mousheng Xu
    • , Hyuk-Soo Seo
    • , Sirano Dhe-Paganon
    • , Nicholas P. Kwiatkowski
    • , Jennifer A. Perry
    • , Jun Qi
    • , Nathanael S. Gray
    •  & James E. Bradner
  • Article |

    Directed evolution of Trp repressor (TrpR) variants that are responsive to halogenated tryptophan analogs and recognize new operator sites serve as useful components for constructing complex gene expression networks.

    • Jared W. Ellefson
    • , Michael P. Ledbetter
    •  & Andrew D. Ellington

News & Comment

  • News & Views |

    Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.

    • Frederick Stull
    •  & James C. A. Bardwell
  • News & Views |

    Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.

    • Andreas K. Brödel
    •  & Mark Isalan
  • News & Views |

    RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.

    • Philip C Bevilacqua
    •  & Sarah M Assmann
  • Commentary |

    Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically relevant positions, ushering in a new era of protein studies.

    • Karl W Barber
    •  & Jesse Rinehart
  • News & Views |

    Early stages of protein evolution are inherently difficult to study. Genetic selection in Escherichia coli has now identified a life-sustaining de novo enzyme arising from a simple scaffold that is completely different from the native enzyme.

    • Kristoffer E Johansson
    •  & Jakob R Winther


Focus on Biomolecular Tailoring

In our March 2018 issue, Nature Chemical Biology presents a collection that explores chemical tailoring of biomolecules within cells and highlights how chemical biology expands our mechanistic understanding of these modified biomolecules and provides tools to illuminate their biological functions.

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