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Latest Research

  • Article |

    Structural, biochemical and cellular studies reveal JMJD7 to be a Jumonji-C oxygenase that catalyzes (3S)-lysyl hydroxylation of the translation factor family of GTPases, DRG1 and DRG2.

    • Suzana Markolovic
    • , Qinqin Zhuang
    • , Sarah E. Wilkins
    • , Charlotte D. Eaton
    • , Martine I. Abboud
    • , Maximiliano J. Katz
    • , Helen E. McNeil
    • , Robert K. Leśniak
    • , Charlotte Hall
    • , Weston B. Struwe
    • , Rebecca Konietzny
    • , Simon Davis
    • , Ming Yang
    • , Wei Ge
    • , Justin L. P. Benesch
    • , Benedikt M. Kessler
    • , Peter J. Ratcliffe
    • , Matthew E. Cockman
    • , Roman Fischer
    • , Pablo Wappner
    • , Rasheduzzaman Chowdhury
    • , Mathew L. Coleman
    •  & Christopher J. Schofield
  • Brief Communication |

    The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.

    • Vincent Wiebach
    • , Andi Mainz
    • , Mary-Ann J. Siegert
    • , Natalia A. Jungmann
    • , Guillaume Lesquame
    • , Sophie Tirat
    • , Assia Dreux-Zigha
    • , Jozsef Aszodi
    • , Dominique Le Beller
    •  & Roderich D. Süssmuth
  • Article |

    The membrane-bound enzyme CybB can directly oxidize superoxide to molecular oxygen and transfer the sequestered electrons to ubiquinone in vitro, providing a mechanism for superoxide scavenging distinct from that of superoxide dismutase.

    • Camilla A. K. Lundgren
    • , Dan Sjöstrand
    • , Olivier Biner
    • , Matthew Bennett
    • , Axel Rudling
    • , Ann-Louise Johansson
    • , Peter Brzezinski
    • , Jens Carlsson
    • , Christoph von Ballmoos
    •  & Martin Högbom
  • Article |

    A single-molecule approach combined with molecular dynamics simulations to examine the conformational dynamics of the Escherichia coli ABC transporter BtuCD defines a coordinated sequence of events leading to unidirectional transport.

    • Min Yang
    • , Nurit Livnat Levanon
    • , Burçin Acar
    • , Burcu Aykac Fas
    • , Gal Masrati
    • , Jessica Rose
    • , Nir Ben-Tal
    • , Turkan Haliloglu
    • , Yongfang Zhao
    •  & Oded Lewinson
  • Article |

    A Rab11 FRET biosensor reveals a spatiotemporal interplay between Rab11 and PtdIns(3)P turnover during the removal of recycling cargo from the endosome.

    • Carlo Cosimo Campa
    • , Jean Piero Margaria
    • , Abhishek Derle
    • , Marco Del Giudice
    • , Maria Chiara De Santis
    • , Luca Gozzelino
    • , Francesca Copperi
    • , Carla Bosia
    •  & Emilio Hirsch
  • Perspective |

    This Perspective explores the diversity, mechanisms and practical aspects of natural and engineered CRISPR-associated nucleases for genome engineering applications.

    • Wen Y. Wu
    • , Joyce H. G. Lebbink
    • , Roland Kanaar
    • , Niels Geijsen
    •  & John van der Oost

News & Comment

  • News & Views |

    Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

    • Lutz Schmitt
  • News & Views |

    Understanding how metals contribute to brain function is a major health priority. A new study combining pharmacology and genetics implicates the accumulation of copper in a brain arousal center as a regulator of zebrafish activity.

    • Jason Rihel

Focus

Focus on Biomolecular Tailoring

In our March 2018 issue, Nature Chemical Biology presents a collection that explores chemical tailoring of biomolecules within cells and highlights how chemical biology expands our mechanistic understanding of these modified biomolecules and provides tools to illuminate their biological functions.

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