Focus


Focus on Development and Disease

Much progress has been made in our understanding of the molecular mechanisms underlying animal development, uncovering numerous links with human disease pathologies.

This issue of Nature Cell Biology presents a series of specially-commissioned articles that highlights how developmental pathways gone awry can cause disease. These articles are available free until the end of February 2008.

The focus is sponsored by the March of Dimes foundation, as well as the Institute of Biochemistry and Cell Biology, Shanghai, and the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences.

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Editorial

Focus on Development and Disease

Developing disease p983

doi:10.1038/ncb0907-983


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Commentaries

Focus on Development and Disease

Human–animal cytoplasmic hybrid embryos, mitochondria, and an energetic debate pp988 - 992

Justin St John & Robin Lovell-Badge

doi:10.1038/ncb436


Focus on Development and Disease

The mouse ascending: perspectives for human-disease models pp993 - 999

Nadia Rosenthal & Steve Brown

doi:10.1038/ncb437


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Perspectives

Focus on Development and Disease

Differentiation plasticity regulated by TGF-beta family proteins in development and disease pp1000 - 1004

Rik Derynck & Rosemary J. Akhurst

doi:10.1038/ncb434


Focus on Development and Disease

Patching the gaps in Hedgehog signalling pp1005 - 1009

Rajat Rohatgi & Matthew P. Scott

doi:10.1038/ncb435


Focus on Development and Disease

Convergent extension and the hexahedral cell pp1010 - 1015

Jeremy B. A. Green & Lance A. Davidson

doi:10.1038/ncb438


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Review

Focus on Development and Disease

Cell polarity in development and cancer pp1016 - 1024

Andreas Wodarz & Inke Näthke

doi:10.1038/ncb433


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