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Convergent extension and the hexahedral cell

Nature Cell Biology volume 9, pages 1010–1015 (2007)Cite this article

During development, embryonic cells sculpt three-dimensional tissues. Although cell polarity is commonly analysed along one, and sometimes two, dimensions, this perspective illustrates how higher-order cell polarity regulates convergent extension — the coordinated cell rearrangement that produces solid tissue elongation.

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Figure 1: Population-, cell- and molecular-level models for convergent extension.
Figure 2: Convergent extension with three-dimensional tissues and cells.

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Acknowledgements

J.B.A.G. was supported by the Biotechnology and Biological Sciences Research Council (BB/D010640) and L.A.D. was supported by the National Institutes of Health (HD044750).

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Authors and Affiliations

  1. Jeremy B. A. Green is in the Department of Craniofacial Development, King's College London, Guys Tower Floor 27, London SE1 9RT, UK.,

    Jeremy B. A. Green

  2. Lance A. Davidson is in the Department of Bioengineering, University of Pittsburgh, 3501 Fifth Avenue, 5059 Biomedical Sciences Tower 3, Pittsburgh 15260, PA, USA. jeremy.green@kcl.ac.uk,

    Lance A. Davidson

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Green, J., Davidson, L. Convergent extension and the hexahedral cell. Nat Cell Biol 9, 1010–1015 (2007). https://doi.org/10.1038/ncb438

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