Volume 16 Issue 12, December 2014

Volume 16 Issue 12

During gastrulation SOX17 coordinates basement membrane assembly and cell intercalation in gut endoderm.p1146

Editorial

  • Editorial |

    Nature Cell Biology explores avenues to optimize the peer-review process and improve author experience.

News and Views

  • News & Views |

    The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.

    • Angela C. H. McDonald
    •  & Janet Rossant
  • News & Views |

    Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.

    • Thomas Sommer
    • , Annika Weber
    •  & Ernst Jarosch
  • News & Views |

    Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.

    • Noboru Mizushima

Articles

  • Article |

    Using time-lapse imaging Hadjantonakis and colleagues have characterized the intercalation of definitive endoderm progenitors into the overlying visceral endoderm during mouse gastrulation and demonstrated a role for the transcription factor SOX17 in this process.

    • Manuel Viotti
    • , Sonja Nowotschin
    •  & Anna-Katerina Hadjantonakis
  • Article |

    Schumacher and colleagues find that the FOXO transcription factor DAF-16 is activated in response to DNA damage in C. elegans and promotes developmental growth in a manner involving EGL-27.

    • Michael M. Mueller
    • , Laia Castells-Roca
    • , Vipin Babu
    • , Maria A. Ermolaeva
    • , Roman-Ulrich Müller
    • , Peter Frommolt
    • , Ashley B. Williams
    • , Sebastian Greiss
    • , Jennifer I. Schneider
    • , Thomas Benzing
    • , Bernhard Schermer
    •  & Björn Schumacher
  • Article |

    Ferroptosis is a form of non-apoptotic cell death with unclear physiological relevance. Conrad and colleagues now report that unrestrained ferroptosis can lead to renal failure. They also identify a small molecule that limits ferroptosis in vivo.

    • Jose Pedro Friedmann Angeli
    • , Manuela Schneider
    • , Bettina Proneth
    • , Yulia Y. Tyurina
    • , Vladimir A. Tyurin
    • , Victoria J. Hammond
    • , Nadja Herbach
    • , Michaela Aichler
    • , Axel Walch
    • , Elke Eggenhofer
    • , Devaraj Basavarajappa
    • , Olof Rådmark
    • , Sho Kobayashi
    • , Tobias Seibt
    • , Heike Beck
    • , Frauke Neff
    • , Irene Esposito
    • , Rüdiger Wanke
    • , Heidi Förster
    • , Olena Yefremova
    • , Marc Heinrichmeyer
    • , Georg W. Bornkamm
    • , Edward K. Geissler
    • , Stephen B. Thomas
    • , Brent R. Stockwell
    • , Valerie B. O’Donnell
    • , Valerian E. Kagan
    • , Joel A. Schick
    •  & Marcus Conrad
  • Article |

    Zhang and colleagues report that starvation reduces O-GlcNAcylation of the SNARE protein SNAP-29. This promotes formation of a competent SNARE complex that increases autophagosome–lysosome fusion, increasing autophagosome maturation and flux.

    • Bin Guo
    • , Qianqian Liang
    • , Lin Li
    • , Zhe Hu
    • , Fan Wu
    • , Peipei Zhang
    • , Yongfen Ma
    • , Bin Zhao
    • , Attila L. Kovács
    • , Zhiyuan Zhang
    • , Du Feng
    • , She Chen
    •  & Hong Zhang
  • Article |

    Mayor and colleagues identify yeast Rsp5 (mammalian homologue Nedd4) as the main ubiquitin ligase responsible for the increased ubiquitylation following heat stress when Rsp5 targets cytosolic misfolded proteins for proteasome degradation.

    • Nancy N. Fang
    • , Gerard T. Chan
    • , Mang Zhu
    • , Sophie A. Comyn
    • , Avinash Persaud
    • , Raymond J. Deshaies
    • , Daniela Rotin
    • , Joerg Gsponer
    •  & Thibault Mayor
  • Article |

    Clarke and colleagues show that TLR2–MYD88 cancer-cell-intrinsic signalling is involved in mammary and colon epithelial regeneration and tumour formation.

    • Ferenc A. Scheeren
    • , Angera H. Kuo
    • , Linda J. van Weele
    • , Shang Cai
    • , Iris Glykofridis
    • , Shaheen S. Sikandar
    • , Maider Zabala
    • , Dalong Qian
    • , Jessica S. Lam
    • , Darius Johnston
    • , Jens P. Volkmer
    • , Debashis Sahoo
    • , Matt van de Rijn
    • , Frederick M. Dirbas
    • , George Somlo
    • , Tomer Kalisky
    • , Michael E. Rothenberg
    • , Stephen R. Quake
    •  & Michael F. Clarke

Letters