Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Gut endoderm takes flight from the wings of mesoderm

Nature Cell Biology volume 16, pages 1128–1129 (2014)Cite this article

Subjects

The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: DE and VE intercalation on the surface of the mouse embryo.

References

  1. Takeichi, M. Nat. Rev. Mol. Cell Biol. 15, 397–410 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. Walck-Shannon, E. & Hardin, J. Nat. Rev. Mol. Cell Biol. 15, 34–48 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Viotti, M., Nowotschin, S. & Hadjantonakis, A-K. Nat. Cell Biol. 16, 1146–1156 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zorn, A. M. & Wells, J. M. Annu. Rev. Cell Dev. Biol. 25, 221–251 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lawson, K. A., Meneses, J. J. & Pedersen, R. A. Dev. Biol. 115, 325–339 (1986).

    Article  CAS  PubMed  Google Scholar 

  6. Lawson, K. A. & Pedersen, R. A. Development 101, 627–652 (1987).

    CAS  PubMed  Google Scholar 

  7. Kwon, G. S., Viotti, M. & Hadjantonakis, A-K. Dev. Cell 15, 509–520 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Vakaet, L. J. Exmbryol. exp. Morph. 10, 38–57 (1962).

    CAS  Google Scholar 

  9. Azar, Y. & Eyal-Giladi, H. J. Embryol. Exp. Morph. 77, 143–151 (1983).

    CAS  PubMed  Google Scholar 

  10. Kimura, W., Yasugi, S., Stern, C. D. & Fukuda, K. Dev. Biol. 289, 283–295 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Ang, S. L. & Rossant, J. Cell 78, 561–574 (1994).

    Article  CAS  PubMed  Google Scholar 

  12. Niakan, K. K. et al. Genes Dev. 24, 312–326 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Cross, J. C., Werb, Z. & Fisher, S. J. Science 266, 1508–1518 (1994).

    Article  CAS  PubMed  Google Scholar 

  14. Bielinska, M., Narita, N. & Wilson, D. B. Int. J. Dev. Biol. 43, 183–205 (1999).

    CAS  PubMed  Google Scholar 

  15. Stern, C. D. & Downs, K. M. Development 139, 1059–1069 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Angela C. H. McDonald and Janet Rossant are in the Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada,

    Angela C. H. McDonald & Janet Rossant

  2. Angela C. H. McDonald is also in the Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada,

    Angela C. H. McDonald

  3. Janet Rossant is also in the Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto Ontario M5S 1A8, Canada,

    Janet Rossant

Authors
  1. Angela C. H. McDonald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Janet Rossant
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Janet Rossant.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

McDonald, A., Rossant, J. Gut endoderm takes flight from the wings of mesoderm. Nat Cell Biol 16, 1128–1129 (2014). https://doi.org/10.1038/ncb3077

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3077

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing