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Rsp5/Nedd4 clears cells of heat-damaged proteins

Nature Cell Biology volume 16, pages 1130–1132 (2014)Cite this article

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Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.

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Figure 1: Proposed activity of Rsp5 and Hul5 in the clearance of heat-damaged proteins.
Figure 2: Distinct ways to integrate ubiquitin ligases into protein quality control pathways.

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Authors and Affiliations

  1. Thomas Sommer, Annika Weber and Ernst Jarosch are at the Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany,

    Thomas Sommer, Annika Weber & Ernst Jarosch

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  1. Thomas Sommer
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  2. Annika Weber
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  3. Ernst Jarosch
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Correspondence to Thomas Sommer.

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Sommer, T., Weber, A. & Jarosch, E. Rsp5/Nedd4 clears cells of heat-damaged proteins. Nat Cell Biol 16, 1130–1132 (2014). https://doi.org/10.1038/ncb3079

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