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Reilein et al. demonstrate that Drosophila ovarian follicle stem cells (FSCs) produce either proliferative follicle cells or quiescent escort cells, depending on which position they occupy in the germarium and in response to graded Wnt signalling.
Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.
Adding to the recent debate on the role of epithelial–mesenchymal transition (EMT) in cancer cell invasion and metastasis, Brabletz and colleagues show that the EMT-inducing transcription factor Zeb1 drives pancreatic tumorigenesis and metastasis.
Damm et al. demonstrate that trunk neural crest cell migration to the dorsal aorta in zebrafish is regulated by platelet-derived growth factor (PDGF) signalling and required for haematopoietic stem cell (HSC) specification.
The Cdc45–MCM–GINS (CMG) complex is needed for DNA replication, but how CMG dissociates from DNA in higher eukaryotes is not clear. Sonneville et al. now characterize pathways for CMG dissociation and replication termination in worm and frog.
Chatzinikolaou et al. show that the nucleotide excision repair complex ERCC1–XPF cooperates with the chromatin organizer CTCF, cohesin subunits and ATRX to facilitate the silencing of a subset of imprinted genes in the developing liver.
Miao et al. show through imaging and mathematical simulations that changing the activation thresholds in an excitable PIP2–Ras–Rap signal transduction network can alter the types of protrusions formed in migrating Dictyostelium cells.
Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.
Zhang et al. show that YAP and TAZ suppress nucleic acid sensing and antiviral responses by inhibiting the TBK1 kinase. Conversely, Hippo pathway activity inactivates YAP/TAZ to relieve TBK1 suppression and enhance antiviral defence in zebrafish.
Using large-scale, super-resolution microscopy, Sochacki et al. define the spatial organization of 19 proteins within clathrin-coated pits during distinct stages of clathrin-mediated endocytosis.
Donato et al. show that Fbxo15 targets acetylated KBP for degradation to limit mitochondrial expansion, whereas KBP accumulation promotes mitochondrial biogenesis in a Kif1Bα-dependent manner.
Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.
Saita et al. show that PARL cleaves Smac (also known as DIABLO) to generate an IAP-binding motif required for its apoptotic activity, identifying PARL-mediated Smac processing as a pro-apoptotic mitochondrial pathway.
Chia et al. show that developmental arrest after human nuclear transfer is associated with genetic instability, including DNA damage, which occurs during DNA replication and is influenced by the developmental origin of the transferred nucleus.
Lilja et al. find that SHANK proteins inhibit the signalling of Ras and Rap G-proteins by restricting their availability at the plasma membrane. This leads to restricted integrin activation, affecting cell spreading, migration and invasion.
Park et al. study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.
Yang and colleagues report that the LINK-A lncRNA binds to the PIP3 phospholipid, leading to enhanced AKT signalling, tumorigenesis and resistance to AKT inhibitors.
Asada et al. examine differential effects of CXCL12 and SCF expression by perivascular bone marrow niche cells, such as arteriolar NG2+ vascular smooth muscle cells and sinusoidal LepR+ cells, on haematopoietic stem cell maintenance and mobilization.
Liu et al. identify an interstitial progenitor cell, characterized by Twist2 expression, that is highly myogenic, forms type IIb/x myofibres and contributes to regeneration in adult skeletal muscle.
Langen et al. identify a third capillary endothelial cell subtype, termed type E, that supports embryonic and early postnatal bone formation, and show that endothelial integrin β1 and laminin α5 are required for bone angiogenesis and osteogenesis.