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Volume 41 Issue 4, April 2023

Fluorescence microscopy

Artistic rendering of nucleosomes labeled with a reversibly switchable green fluorescent protein and portrayed as spinning tops on a plate. Volpato et al. developed a method that extends fluorescence anisotropy measurements to large protein complexes.

See Volpato et al.

Image: cover art conceptualized by Andrea Volpato and realized by Ella Maru Studio (scientific-illustrations.com). Cover design: Erin Dewalt.

Volume 41 Issue 4

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Editorial

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Correspondence

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Q&A

  • A group of experts reflects on what was learned from the first human transplants of genetically engineered pig organs and what the future of xenotransplantation may hold.

    • Kathryn Aschheim
    • Laura DeFrancesco
    Q&A
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  • Patents

    • Patent office data show robust and rising patenting of AI inventions in the medical field, contrary to fears that medical machine learning patents might be largely unavailable because of challenges to their subject-matter eligibility.

      • Mateo Aboy
      • W. Nicholson Price II
      • Seth Raker
      Patents

    • Recent patents relating to microfluidic devices and methods for high-throughput phenotyping and sample preparation methods.

      Patents
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Research Briefings

  • Spatial total RNA-sequencing (STRS) combines in situ polyadenylation with existing spatial transcriptomics technologies to enable a broader view of the transcriptome in tissues. We use STRS to spatially map coding, noncoding and nonhost RNAs in models of skeletal muscle regeneration and viral myocarditis.

    Research Briefing

  • The ability to target the majority of human transcription factors remains an as yet unachieved goal in chemical biology and medicine. We developed a modular, synthetic transcriptional repressor platform that recapitulates the DNA-binding properties of native basic helix-loop-helix (bHLH) domains and can block the DNA-binding functions of an important oncogenic transcription factor target, MYC.

    Research Briefing
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