Nature Biotechnology

Volume 34 Issue 7, July 2016

A scanning electron micrograph of bone tissue. The bone marrow (orange) provides the niche for hematopoietic stem cells. Palchaudhuri et al. describe an antibody-based agent for depleting cells in the bone marrow before hematopoietic stem cell transplantation (p 738). Image credit: Steve Gschmeissner, Science Source

Volume 34 Issue 7

Editorial

Rewriting our future

Headlines about a proposal to engineer an entirely synthetic human genome largely missed the point.

Editorial 12 Jul 2016

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News

Duchenne muscular dystrophy drugs at the crossroads, as newer agents advance

Cormac Sheridan
News 12 Jul 2016
Neural stem cell trailblazer StemCells folds

Eric Smalley
News 12 Jul 2016
FDA snubs first smart pill

News 12 Jul 2016
Outlook for NGF inhibitor painkiller class brightens

Kelly Rae Chi
News 12 Jul 2016
Mayo Clinic to share 1 million

News 12 Jul 2016
Biogen's once-monthly MS injection gets FDA nod

News 12 Jul 2016
FDA wades into sequencing-based diagnostics regulation

Justin Petrone
News 12 Jul 2016
Stemcentrx bags $5.8 billion, even as Notch agent underwhelms

Eva von Schaper
News 12 Jul 2016
First EU PRIME designations

News 12 Jul 2016
Organ delivery by 1,000 drones

Michael Francisco
News 12 Jul 2016
Around the world in a month

News 12 Jul 2016

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Bioentrepreneur

The value of royalty

Academic institutions need to prioritize how they incorporate terms for royalty streams into license agreements.

Michael A Reslinski
Bernhard S Wu
Bioentrepreneur 12 Jul 2016

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Correspondence

Saturation analysis for whole-genome bisulfite sequencing data

Emanuele Libertini
Simon C Heath
Stephan Beck
Correspondence 27 Jun 2016
How China can enhance adoption of biotech crops

Fei Han
Anthony M Shelton
Dingyang Zhou
Correspondence 12 Jul 2016
European incoherence on GMO cultivation versus importation

Giovanni Tagliabue
Correspondence 12 Jul 2016
Analyzing CRISPR genome-editing experiments with CRISPResso

Luca Pinello
Matthew C Canver
Guo-Cheng Yuan
Correspondence 12 Jul 2016
Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data

Mayur Sarangdhar
Scott Tabar
Bruce J Aronow
Correspondence 12 Jul 2016
CrispRVariants charts the mutation spectrum of genome engineering experiments

Helen Lindsay
Alexa Burger
Mark D Robinson
Correspondence 12 Jul 2016
Software tools for single-cell tracking and quantification of cellular and molecular properties

Oliver Hilsenbeck
Michael Schwarzfischer
Timm Schroeder
Correspondence 12 Jul 2016
Plant specific N-glycans do not have proven adverse effects in humans

Yoseph Shaaltiel
Yoram Tekoah
Correspondence 12 Jul 2016

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Feature

Public biotech in 2015 – the numbers

Last year witnessed the biotech sector's first retreat from a multi-year run of incredible performance on the public markets.

Chris Morrison
Riku Lähteenmäki
Feature 12 Jul 2016

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Patents

Are reverse payments and pay-for-delay settlements business as usual or an anticompetitive practice?

Cash payments and other arrangements between patent holders and their competitors in exchange for a delayed market entry interfere with free-market principles and keep product prices at a premium, which affects payers, governments, healthcare providers and especially patients.

Swati Shah
Matthew A Silva
Michael J Malloy
Patents 12 Jul 2016
Recent patents in gene editing

Patents 12 Jul 2016

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News & Views

Safer conditioning for blood stem cell transplants

An antibody-based conditioning agent may open the way to wider application of gene therapy with hematopoietic stem cells.

Alessandro Aiuti
Luigi Naldini
News & Views 12 Jul 2016
Tracking translation one mRNA at a time

Imaging of single mRNA molecules undergoing translation provides insights into the regulation of protein synthesis.

Jiahui Wu
Samie R Jaffrey
News & Views 12 Jul 2016
Research Highlights

News & Views 12 Jul 2016
Tracing cell lineages with mutable barcodes

João H Duarte
News & Views 12 Jul 2016

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Analysis

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

A multicenter comparison of DNA methylation assays identifies robust methods for translational research and clinical diagnostics.

Christoph Bock
Florian Halbritter
Kun Zhang
Analysis Open Access 27 Jun 2016

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Article

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

An antibody-based conditioning agent enables hematopoietic stem cell transplantation in immunocompetent mice with less toxicity than irradiation.

Rahul Palchaudhuri
Borja Saez
David T Scadden
Article 06 Jun 2016
Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids

Gene therapy is switched on and off by changes in diet.

Cédric Chaveroux
Alain Bruhat
Pierre Fafournoux
Article 06 Jun 2016
An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy

An artificial niche prolongs the quiescence of muscle stem cells in vitro.

Marco Quarta
Jamie O Brett
Thomas A Rando
Article 30 May 2016
A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo

In vivo imaging is facilitated by a bright, cyan-excitable orange fluorescent protein that is the basis of an improved bioluminescent protein.

Jun Chu
Younghee Oh
Michael Z Lin
Article 30 May 2016
DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

Genome editing guided by a short single-stranded DNA is achieved with a nuclease from an archaebacterium.

Feng Gao
Xiao Z Shen
Chunyu Han
Article 02 May 2016

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Letter

A split horseradish peroxidase for the detection of intercellular protein–protein interactions and sensitive visualization of synapses

Synapses can be detected with high sensitivity by a split reporter that visualizes intercellular protein–protein interactions.

Jeffrey D Martell
Masahito Yamagata
Alice Y Ting
Letter 30 May 2016

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Careers and Recruitment

Boosting the career development of postdocs with a peer-to-peer mentor circles program

Mentor circles combine the advantages of both mentoring networks and peer-to-peer mentoring.

Chantal Kuhn
Zafira Castaño

Career Guide:

Mentoring resources for scientists
Careers and Recruitment 12 Jul 2016
People

Careers and Recruitment 12 Jul 2016

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