Volume 34 Issue 6, June 2016

Crop losses caused by plant pathogens are managed by either planting resistant varieties or using pesticides. A trio of papers from The Sainsbury Laboratory in Norwich, UK, provides evidence that engineering pathogen resistance could provide sustainable genetic solutions to crop pests and pathogens. In one report, soybean is made resistant to Asian soybean rust using a gene cloned from the orphan legume pigeonpea (p 661). In two accompanying reports, resistance genes for potato late-blight and wheat stem rust are identified by developing rapid resistance-gene cloning methods (pp 656 and 652). Image credit: Andrew Davis, John Innes Centre, Norwich, UK; The hands are from: Kamik Witek (potato), Burkhard Steuernagel (wheat) and Kim Wood (soybean).

Editorial

No guarantees in translation

A drug company executive thinks academic institutions should give money back for research that turns out to be 'irreproducible'.

Editorial 09 Jun 2016

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News

Gilead bets big on Nimbus' fatty liver disease drug

Mark Ratner
News 09 Jun 2016
Bristol-Myers Squibb locks into novel autoimmune strategy

Ken Garber
News 09 Jun 2016
Consortium nurtures ex vivo gene therapy firm

Laura DeFrancesco
News 09 Jun 2016
Matchmaker for NIH-rejected grants

Michael Francisco
News 09 Jun 2016
White House unveils National Microbiome Initiative

Aaron Bouchie
News 09 Jun 2016
Amgen/UCB build on bone franchise with anti-sclerostin antibody

Suzanne Elvidge
News 09 Jun 2016
CRISPR-edited crops free to enter market, skip regulation

Emily Waltz
News 09 Jun 2016
Tech billionaires fund new cancer centers

News 09 Jun 2016
AstraZeneca nabs genomics giants

News 09 Jun 2016
Around the world in a month

News 09 Jun 2016

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Bioentrepreneur

Research institute partnerships 2015

Brady Huggett
Bioentrepreneur 09 Jun 2016
First Rounders Podcast: Tom Maniatis

Brady Huggett
Bioentrepreneur 09 Jun 2016

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Correspondence

The president says patients should own their genetic data. He's wrong

Jorge L Contreras

Nature Outlook:

Precision medicine
Correspondence 09 Jun 2016
Why patients shouldn't “own” their medical records

John Rumbold
Barbara Pierscionek

Nature Outlook:

Precision medicine
Correspondence 09 Jun 2016
Reply to Why patients shouldn't “own” their medical records

Nature Outlook:

Precision medicine
Correspondence 09 Jun 2016
Research that is fit to print

Harlan W Waksal
Correspondence 09 Jun 2016
Reply to Research that is fit to print

Correspondence 09 Jun 2016
Secure cloud computing for genomic data

Somalee Datta
Keith Bettinger
Michael Snyder
Correspondence 09 Jun 2016
The contribution of cell cycle to heterogeneity in single-cell RNA-seq data

Andrew McDavid
Greg Finak
Raphael Gottardo
Correspondence 09 Jun 2016
Reply to The contribution of cell cycle to heterogeneity in single-cell RNA-seq data

Andrew McDavid
Greg Finak
Raphael Gottardo
Correspondence 06 May 2016

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Feature

Cancer moonshot countdown

Nature Biotechnology asks representatives from three different cancer 'moonshot' initiatives to outline their visions.

Douglas Lowy
Dinah Singer
Patrick Soon-Shiong
Feature 09 Jun 2016
Gene therapy's out-of-body experience

With an approval likely at the EMA, ex vivo gene therapy in hematopoietic stem cells appears poised for prime time.

Christopher Thomas Scott
Laura DeFrancesco
Feature 09 Jun 2016
Biotech's wellspring—a survey of the health of the private sector in 2015

The eagerness of non-traditional biotech investors made for another good year for the industry. Will it continue?

Brady Huggett
Feature 09 Jun 2016

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Patents

The morality and ethics governing CRISPR–Cas9 patents in China

Chinese patent law may not be equipped to deal with the potential moral issues raised by gene-editing technology.

Yaojin Peng
Patents 09 Jun 2016
Recent patents in organoids

Patents 09 Jun 2016

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News & Views

Resistance from relatives

Crops are made resistant to pathogens such as wheat stem rust, Asian soybean rust and potato late blight by methods to access the pool of resistance genes present in related plants.

Andrew Bent
News & Views 09 Jun 2016
Comparing CRISPR and RNAi-based screening technologies

Two studies provide an experimental side-by-side comparison of genetic screening methods.

Benjamin E Housden
Norbert Perrimon
News & Views 09 Jun 2016
The minimal genome comes of age

A genome smaller than any known natural or reduced genome has been designed, synthesized and shown capable of sustaining self-replication in a free-living environment.

Claudia E Vickers
News & Views 09 Jun 2016
Research Highlights

News & Views 09 Jun 2016

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Perspective

The US regulatory and pharmacopeia response to the global heparin contamination crisis

Anita Y Szajek
Edward Chess
Ali Al-Hakim
Perspective 09 Jun 2016

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Brief Communication

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

CRISPR knockout screens outperform shRNA and CRISPR-interference screens in a side-by-side comparison.

Bastiaan Evers
Katarzyna Jastrzebski
Rene Bernards
Brief Communication 25 Apr 2016
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

A side-by-side comparison of CRISPR/Cas9 and RNAi screens for essential genes reveals method-specific differences in performance.

David W Morgens
Richard M Deans
Michael C Bassik
Brief Communication 09 May 2016

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Article

Wishbone identifies bifurcating developmental trajectories from single-cell data

Cell differentiation is accurately modeled by an algorithm that orders single cells along branched developmental trajectories.

Manu Setty
Michelle D Tadmor
Dana Pe'er
Article 02 May 2016

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Letter

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

A small-molecule-inducible Cas9 variant with very low background activity is identified by screening for sites that can tolerate domain insertions.

Benjamin L Oakes
Dana C Nadler
David F Savage
Letter 02 May 2016
Rapid cloning of disease-resistance genes in plants using mutagenesis and sequence capture

A method for rapid cloning of plant disease-resistance genes could provide sustainable, genetic solutions to crop pests and pathogens in place of agrichemicals.

Burkhard Steuernagel
Sambasivam K Periyannan
Brande B H Wulff
Letter 25 Apr 2016
Accelerated cloning of a potato late blight–resistance gene using RenSeq and SMRT sequencing

A method for rapid cloning of plant disease-resistance genes could provide sustainable genetic solutions to crop pests and pathogens in place of agrichemicals.

Kamil Witek
Florian Jupe
Jonathan D G Jones
Letter 25 Apr 2016
A pigeonpea gene confers resistance to Asian soybean rust in soybean

Soybean is made resistant to Asian soybean rust using a gene cloned from pigeonpea, showing that legumes may contain a reservoir of disease-resistance genes.

Cintia G Kawashima
Gustavo Augusto Guimarães
Sérgio H Brommonschenkel
Letter 25 Apr 2016

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Erratum

Erratum: 20 years of Nature Biotechnology research tools

Anna Azvolinsky
Laura DeFrancesco
Sarah Webb
Erratum 09 Jun 2016
Erratum: 20 years of Nature Biotechnology biomedical research

Anna Azvolinsky
Charles Schmidt
Sarah Webb
Erratum 09 Jun 2016
Erratum: When biotech goes bad

John Hodgson
Erratum 09 Jun 2016
Erratum: Community crystal gazing

Anu Acharya
Kate Bingham
Daphne Zohar
Erratum 09 Jun 2016

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Corrigendum

Correction: Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

Arturo J Vegas
Omid Veiseh
Daniel G Anderson
Corrigendum 09 Jun 2016

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Careers and Recruitment

Compensation inflation remains consistent at private life science companies

Non-founder total target cash compensation increased 3.3% at private life science companies in 2015.

Bruce Rychlik
Careers and Recruitment 09 Jun 2016
People

Careers and Recruitment 09 Jun 2016

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Volume 34 Issue 6, June 2016

Editorial

News

Bioentrepreneur

Correspondence

Feature

Patents

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