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Volume 30 Issue 5, May 2012

Microorganisms from a mud sample collected in Lake Washington (Seattle). Zhang and colleagues describe a new approach to cloning that facilitates the identification of natural products from sequenced microorganisms or metagenomic samples (p 440). Credit: ©Dennis Kunkel Microscopy (colorization by Ekaterina Latypova). Sample from Mila Chistoserdova, University of Washington, Seattle.

Volume 30 Issue 5

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Editorial

  • The European Medicines Agency's request to make all clinical trial data available is key to countering bias in publication, drug prescription practice and health policy.

    Editorial

    Advertisement

  • Controversies surrounding government walk-in rights or patent eligibility that grabbed headlines in recent weeks presage broader changes in biomarker patenting.

    Editorial
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News

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Data Page

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News Feature

  • Can the commercial sector capitalize on the merger of high-throughput technology and natural products? Cormac Sheridan investigates.

    • Cormac Sheridan
    News Feature
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Bioentrepreneur

  • In life sciences, a successful company very often looks markedly different from what was envisioned at founding.

    • Bill Polvino
    Bioentrepreneur
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Correspondence

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Feature

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Patents

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News & Views

  • The discovery of an efficient mechanism of homologous recombination between two linear DNA substrates provides a new method for direct cloning.

    • Ryan E Cobb
    • Huimin Zhao
    News & Views
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Research Highlights

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Analysis

  • Tumors vary in their ratio of normal to cancerous cells and in their genomic copy number. Carter et al. describe an analytic method for inferring the purity and ploidy of a tumor sample, enabling longitudinal studies of subclonal mutations and tumor evolution.

    • Scott L Carter
    • Kristian Cibulskis
    • Gad Getz
    Analysis
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Perspective

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Analysis

  • Small sequencing machines no bigger than a laser printer have many potential applications in diagnostics and public health. Loman et al. compare the quality, throughput and cost of instruments from Illumina, Roche and Life Technologies.

    • Nicholas J Loman
    • Raju V Misra
    • Mark J Pallen
    Analysis
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Article

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Resource

  • Transcription activator–like effector nucleases (TALENs) enable genetic modification at specific sites in a genome. Reyon et al. present a method for high-throughput generation of TALENs, facilitating large-scale genome engineering.

    • Deepak Reyon
    • Shengdar Q Tsai
    • J Keith Joung
    Resource
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Erratum

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Careers and Recruitment

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In This Issue

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