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Crystal structure of an optimized protein inhibitor (F-HB80.4) bound to the SC1918 H1 influenza hemagglutinin ectodomain. Whitehead et al. describe a deep-sequencing approach to increase the binding affinity of computationally designed inhibitors (p 543). Credit: Tim Whitehead.
Comparative effectiveness, especially in its new guise of patient-centered outcomes research, is all the rage in US policy circles. Will it really make a difference to healthcare? Mark Ratner reports.
Locking in a potential partner and executing a license for development and commercialization requires honed negotiation skills. Here's how not to blink.
Patents on genes and other types of biomarkers have caused much controversy, but their importance to diagnostic innovation is in danger of being overlooked.
Encouraging more broad and inclusive data sharing in today's world will involve concerted community efforts to overcome technical barriers and human foibles. Vivien Marx investigates.
Analyzing the effects of multiple promoter motifs on gene expression can be a laborious process. Sharon et al. present a high-throughput method to measure the expression of thousands of designed yeast promoters in a single experiment and use it to reveal new features of transcriptional regulation.
Drukker and colleagues differentiated human embryonic stem (ES) cells for 3 days and screened the cells for labeling by >400 antibodies. They identified cell-surface markers expressed on four classes of early progenitor cell.
To increase the affinity of designed protein inhibitors for influenza hemagglutinin, Whitehead et al. use yeast display and deep sequencing to measure the effects on binding of ~1,000 amino-acid substitutions. Rare beneficial mutations are then combined and screened, yielding inhibitors with ~25-fold lower dissociation constants.
Completion of genome sequences for the diploid Setaria italica reveals features of C4 photosynthesis that could enable improvement of the polyploid biofuel crop switchgrass (Panicum virgatum). The genetic basis of biotechnologically relevant traits, including drought tolerance, photosynthetic efficiency and flowering control, is also highlighted.
Completion of genome sequences for the diploid Setaria italica reveals features of C4 photosynthesis that could enable improvement of the polyploid biofuel crop switchgrass (Panicum virgatum). The genetic basis of biotechnologically relevant traits, including drought tolerance, photosynthetic efficiency and flowering control, is also highlighted.
