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Volume 30 Issue 4, April 2012

A strand of DNA is released from a 'blocking oligomer' (red) and poised for ratcheting by phi29 DNA polymerase (coral) through an MspA protein nanopore (blue). Akeson and colleagues robustly control the speed of DNA translocation through a nanopore (p 344), and Gundlach and colleagues show that this enables single nucleotide-resolution analysis of the DNA bases (p 349). Credit: ©Kenneth Eward.

Editorial

  • Proposed US legislation aiming to expand and expedite patient access to novel drugs represents a good start, but is unlikely to strongly boost approval numbers.

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News

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News Feature

  • US biotech seems reenergized, but unsettled policy questions take a back seat to pending national elections, particularly with the presidency at stake. Jeffrey L Fox reports.

    • Jeffrey L Fox
    News Feature
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Bioentrepreneur

  • Securing a partner is only the beginning—you then have to put substantial effort and resources into keeping the collaboration functioning and productive.

    • Garry E Menzel
    • Kleanthis G Xanthopoulos
    Bioentrepreneur
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Correspondence

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Patents

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News & Views

  • Major hurdles in the quest to sequence DNA with biological nanopores have now been overcome.

    • Grégory F Schneider
    • Cees Dekker
    News & Views
  • A cancer vaccine is streamlined by identifying a small set of potent immunogens in a tumor cDNA library.

    • Francesca Avogadri
    • Jedd D Wolchok
    News & Views
  • Two head-to-head comparisons of genome assembly methods highlight the best performers and outstanding problems.

    • Wei Fan
    • Ruiqiang Li
    News & Views
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Research Highlights

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News Feature

  • A new statistical method called MIC can find diverse types of correlations in large data sets. Nature Biotechnology asked eight experts to weigh in on its utility.

    News Feature
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Article

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Letter

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Erratum

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Careers and Recruitment

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