Nature Biotechnology

Volume 21 Issue 2, February 2003

Cover shows budding yeast superimposed on a steroid metabolic pathway. On p. 143, Dumas and colleagues demonstrate that rewiring of metabolic networks in yeast shows promise for biosynthesis of complex molecules of pharmaceutical interest from simple carbon sources. Yeast image © Photo Researchers.

Volume 21 Issue 2

Editorial

Generating copy(s)

Editorial 01 Feb 2003

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Business and Regulatory News

Ambitious French biotech plan faces EU hurdle

John Hodgson
Business and Regulatory News 01 Feb 2003
Cash crunch quells antibody litigation

Peter Mitchell
Business and Regulatory News 01 Feb 2003
Lymphoma market turf war imminent, pending Bexxar approval

Ken Garber
Business and Regulatory News 01 Feb 2003
US policy on data disclosure debated

Jeffrey L. Fox
Business and Regulatory News 01 Feb 2003
India set to embrace GM rice

K.S. Jayaraman
Business and Regulatory News 01 Feb 2003
In Brief

Business and Regulatory News 01 Feb 2003

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Commentary

The changing norms of the life sciences

Peter Shorett
Paul Rabinow
Paul R. Billings
Commentary 01 Feb 2003
The price of conserving agricultural biodiversity

Bonwoo Koo
Philip Pardey
Brian Wright
Commentary 01 Feb 2003

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Fools Corner

Let the chips fall where they may

Tom Jacobs
Fools Corner 01 Feb 2003

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Correspondence

Outside expertise

Nikos Panayotatos
Correspondence 01 Feb 2003
RNAi targeting of DNA virus in plants

Mikhail Pooggin
P. V. Shivaprasad
Thomas Hohn
Correspondence 01 Feb 2003
Liabilities and economics of transgenic crops

Correspondence 01 Feb 2003

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Erratum

Erratum: Seeking sweet relief for diabetes

Erratum 01 Feb 2003
Erratum: US panel advises resumption of gene trials

Erratum 01 Feb 2003
Erratum: Expectations and reality in gene repair

Erratum 01 Feb 2003
Erratum: The sigmoidal curve of cancer

Erratum 01 Feb 2003

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News & Views

Rewiring yeast for drug synthesis

Metabolic engineering on a grand scale has produced yeast that can synthesize hydrocortisone.

Diane Kelly
Steven Kelly
News & Views 01 Feb 2003
Vitamin C booster

Identification and manipulation of a new enzyme from strawberry demonstrates the feasibility of engineering vitamin C synthesis in plants.

Nicholas Smirnoff
News & Views 01 Feb 2003
Pseudomonas putida—a versatile biocatalyst

Genomic analysis of Pseudomonas putida sheds light on metabolic pathways that may be exploited for a variety of biotechnological applications.

Lawrence P. Wackett
News & Views 01 Feb 2003
Designer milk from transgenic clones

Biotechnology gets a step closer in the pre-harvest production of “new milks” by generating cows that overexpress casein proteins in their milk.

Costas N. Karatzas
News & Views 01 Feb 2003

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News in Brief

In Brief

News in Brief 01 Feb 2003

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Article

Total biosynthesis of hydrocortisone from a simple carbon source in yeast

Florence Ménard Szczebara
Cathy Chandelier
Bruno Dumas
Article 06 Jan 2003
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains

Manor Askenazi
Edward M. Driggers
Kevin T. Madden
Article 21 Jan 2003
Cloned transgenic cattle produce milk with higher levels of β-casein and κ-casein

Brigid Brophy
Grant Smolenski
Götz Laible
Article 27 Jan 2003
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

Michael J. Feldhaus
Robert W. Siegel
K. Dane Wittrup
Article 21 Jan 2003
Lipopeptide detergents designed for the structural study of membrane proteins

Clare-Louise McGregor
Lu Chen
Gilbert G. Privé
Article 13 Jan 2003
Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase

Fernanda Agius
Rocío González-Lamothe
Victoriano Valpuesta
Article 13 Jan 2003

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Technical Report

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

Qi-Long Ying
Marios Stavridis
Austin Smith
Technical Report 13 Jan 2003
A genomics-guided approach for discovering and expressing cryptic metabolic pathways

Emmanuel Zazopoulos
Kexue Huang
Chris M. Farnet
Technical Report 21 Jan 2003
Kindling fluorescent proteins for precise in vivo photolabeling

Dmitriy M. Chudakov
Vsevolod V. Belousov
Konstantin A. Lukyanov
Technical Report 13 Jan 2003
A high-throughput nonisotopic protein truncation test

Sadanand Gite
Mark Lim
Kenneth Rothschild
Technical Report 13 Jan 2003

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Corrigendum

Correction: Corrigendum: Arrayed adenoviral expression libraries for functional screening

Frits Michiels
Helmuth van Es
Peter Tomme
Corrigendum 01 Feb 2003

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Erratum

Erratum: Screening for gene function in chicken embryo using RNAi and electroporation

Vladimir Pekarik
Dimitris Bourikas
Esther T. Stoeckli
Erratum 01 Feb 2003

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Patents

Workplace programs to protect trade secrets

Trade secret protection programs can be effective in preventing the loss of valuable company information and intellectual property assets, if appropriately implemented.

Kerry Medd
Antoinette Konski
Patents 01 Feb 2003
Recent patents in nanotechnology

Patents 01 Feb 2003

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People

People

People 01 Feb 2003

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New on the Market

Chromatography and Thermocycling

New on the Market 01 Feb 2003

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Careers and Recruitment

Transferable skills for a competitive edge

Mastering the 'soft' skills can convince prospective employers of your potential.

Paul Watson
Careers and Recruitment 01 Feb 2003

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