Reviews & Analysis

Targeting by tissue-specific microRNAs enhances the efficacy and safety of tumor-killing viruses.

A component of the complement system promotes tumor growth by activating myeloid-derived suppressor cells.

An integrated microfluidic device enables rapid detection of protein biomarkers in patient samples.

Antibody-tagged carbon nanotubes permit sensitive detection on protein microarrays by surface-enhanced Raman scattering.

Several new approaches for generating induced pluripotent stem cells reduce the risk of insertional mutagenesis.

High-throughput sequencing rapidly connects microbial phenotypes and genotypes to guide metabolic engineering.

Induced pluripotent stem cells have been generated from single human hairs, providing an easily accessible source of cells amenable to efficient reprogramming.

A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.

Global RNA interference screens uncover the host genes that support infection by HIV, West Nile virus and influenza virus.

The ability to quantify carbon fluxes in mammalian cells is a step toward elucidating the dynamic metabolic networks associated with health and disease.

Pancreatic acinar cells have been reprogrammed in vivo into insulin-expressing cells by adenoviral delivery of three transcription factors.

A targeted metagenomics approach profiles the methylotrophic microbes in lake sediments.

A less-virulent poliovirus generated by altering codon usage suggests a new strategy for vaccine development.

In addition to its plasmid DNA, Agrobacterium tumefaciens can transfer its chromosomal DNA to plant genomes.

The genome sequence of the plant-parasitic roundworm Meloidogyne incognita opens new avenues to boosting food production.

Near-uniform, low-level conjugation of cytotoxins to antitumor antibodies increases their tolerability without compromising efficacy.