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Enhancing immunity to HIV through APOBEC

Nature Biotechnology volume 26, pages 1089–1090 (2008)Cite this article

A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.

In the search for new classes of drugs against HIV, the human antiviral protein APOBEC3G (A3G)1,2 and its viral antagonist Vif have recently emerged as attractive targets. In this issue, Nathans et al.3 describe the discovery of small molecules that help A3G to evade Vif and thus to restrict HIV infection. These findings provide an important proof of concept that small molecules can indeed target the A3G-Vif axis to favorably tip the balance of this host-pathogen conflict.

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Figure 1: Targeting the A3G-Vif axis.

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Affiliations

  1. Reuben Harris is in the Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology and Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA. rsh@umn.edu

    Reuben S Harris

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  1. Reuben S Harris
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Harris, R. Enhancing immunity to HIV through APOBEC. Nat Biotechnol 26, 1089–1090 (2008). https://doi.org/10.1038/nbt1008-1089

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  • DOI: https://doi.org/10.1038/nbt1008-1089

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