Reviews & Analysis

Lamprey monoclonal antibodies provide stable and high-avidity alternatives to immunoglobulins.

Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.

Research on mitochondria will benefit from a new compendium of genetic and physiological data.

An entire bacterial genome has been reconstructed by stitching together chemically synthesized DNA fragments, bringing the prospect of an artificial living organism one step closer.

The ability to produce 'higher-chain' alcohols in Escherichia coli could pave the way for advanced biofuels.

Color-coded probe pairs enable multiplexed gene expression analysis with a sensitivity that rivals PCR-based methods.

A new label-free method for RNA detection uses programmable DNA tiles and atomic force microscopy.

Photoreceptor-like cells generated from embryonic stem cells hold promise for treating diseases of the retina.

Regulatory T cells may prevent acute and chronic rejection of organ transplants.

The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets.

Technologies for selecting segments of large genomes for resequencing will reveal biologically important sequence variation.

Integrating data from glycan microarrays and X-ray structures sheds light on human adaptation of influenza viruses.

A new mouse model with humanized blood vessels will facilitate testing of antiplatelet therapies.

The derivation of primate embryonic stem cells by nuclear transfer marks an advance toward human therapeutic cloning.

Induced pluripotent stem cells have been generated from mouse and human adult fibroblasts without the tumor-causing gene c-Myc.