Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A crystal clear view of the β2-adrenergic receptor

Nature Biotechnology volume 26, pages 189–191 (2008)Cite this article

The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structures of the β2-adrenergic receptor and rhodopsin.

References

  1. Pierce, K.L., Premont, R.T. & Lefkowitz, R.J. Nat. Rev. Mol. Cell Biol. 3, 639–650 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Palczewski, K. et al. Science 289, 739–745 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Salom, D. et al. Proc. Natl. Acad. Sci. USA 103, 16123–16128 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rasmussen, S.G. et al. Nature 450, 383–387 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Cherezov, V. et al. Science 318, 1258–1265 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rosenbaum, D.M. et al. Science 318, 1266–1272 (2007).

    CAS  PubMed  Google Scholar 

  7. Lefkowitz, R.J., Rajagopal, K. & Whalen, E.J. Mol. Cell 24, 643–652 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. Dixon, R.A. et al. Nature 321, 75–79 (1986).

    Article  CAS  PubMed  Google Scholar 

  9. Corless, J.M., McCaslin, D.R. & Scott, B.L. Proc. Natl. Acad. Sci. USA 79, 1116–1120 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Okada, T. et al. J. Mol. Biol. 342, 571–583 (2004).

    Article  CAS  PubMed  Google Scholar 

  11. Day, P.W. et al. Nat. Methods 4, 927–929 (2007).

    Article  CAS  PubMed  Google Scholar 

  12. Lefkowitz, R.J. Cotecchia, S., Samama, P. & Costa, T. Trends Pharmacol.Sci. 14, 303–307 (1993).

    Article  CAS  PubMed  Google Scholar 

  13. Kjelsberg, M.A., Cotecchia, S., Ostrowski, J., Caron, M.G. & Lefkowitz, R.J.J. J. Biol. Chem. 267, 1430–1433 (1992).

    CAS  PubMed  Google Scholar 

  14. Ballesteros, J.A. et al. J. Biol. Chem. 276, 29171–29177 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. Wisler, J.W. et al. Proc. Natl. Acad. Sci. USA 104, 16657–16662 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Robert J. Lefkowitz is in the Departments of Medicine and Biochemistry and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA. lefko001@receptor-biol.duke.edu,

    Robert J Lefkowitz

  2. Jin-Peng Sun and Arun K. Shukla are in the Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.,

    Jin-Peng Sun & Arun K Shukla

Authors
  1. Robert J Lefkowitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin-Peng Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arun K Shukla
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lefkowitz, R., Sun, JP. & Shukla, A. A crystal clear view of the β2-adrenergic receptor. Nat Biotechnol 26, 189–191 (2008). https://doi.org/10.1038/nbt0208-189

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0208-189

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing