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In studies using mouse models of psoriasis, a spectrum of innate lymphoid cell types is reconfigured and converges via multiple trajectories on a type 3-like state, demonstrating the range and flexibility of innate lymphoid cell responses in the skin.
X-ray crystallography and cryo-electron microscopy structures of the transcriptional repressor of the methylomycin gene cluster, MmfR, reveal the molecular basis for regulation of antibiotic biosynthesis by AHFCA hormones in Actinobacteria.
The authors present EpiMap, a compendium that comprises 10,000 epigenomic maps across more than 800 biosamples for the annotation of genome-wide association study circuitry.
A family of topological antiferromagnetic spin textures is realized at room temperature in α-Fe2O3, and their reversible and field-free stabilization using a Kibble–Zurek-like temperature cycling is demonstrated.
Unexpected intervals of low 230Th concentration in marine sediment cores are explained by considering that during at least two such periods, the Arctic Ocean and Nordic seas were composed entirely of fresh water and covered by a thick ice shelf.
Single-stranded, DNA-damage-associated small RNAs generated by a BRCA1–RNA-interference complex promote PALB2–RAD52-mediated DNA repair at transcriptional termination pause sites that contain R-loops and are rich in single-stranded DNA breaks in both quiescent and proliferating cells.
An einsteinium coordination complex is synthesized and spectroscopically characterized using less than 200 nanograms of einsteinium, enabling examination of its structure and measurement of an einsteinium bond distance.
An approach called the Ramanujan Machine demonstrates the use of algorithms to find mathematical conjectures in the form of formulas of fundamental constants, some of which remain unproved.
In patients with high-grade serous ovarian cancer, robust and protective humoral responses are dominated by B-cell-derived polyclonal IgA that binds to polymeric IgA receptors that are universally expressed on ovarian cancer cells.
T follicular helper cells undergo antigen-dependent selection in germinal centres, with higher-affinity T cell receptors supporting stronger proliferation leading to their clonal dominance.
Highly tunable moiré superconductivity is observed in magic-angle twisted trilayer graphene, and observations suggest that this superconductor can be tuned close to the crossover to a two-dimensional Bose–Einstein condensate.
BNT162b1 and BNT162b2 are two candidate mRNA vaccines against COVID-19 that elicit high virus-entry inhibition titres in mice, elicit high virus-neutralizing titres in rhesus macaques and protect macaques from SARS-CoV-2 challenge.
Primed pluripotent stem cells from distant species compete with each other, and inactivation of NF-κB signalling in normally outcompeted human cells improves their survival and chimerism in mouse embryos.
A fossil of the Middle Jurassic haramiyidan Vilevolodon diplomylos with a well-preserved malleus, incus and ectotympanic sheds light on the evolutionary transition from a dual to a single function for the ossicles in mammals.
A modular de novo designed biosensor platform consisting of a cage and key molecule is developed, and used to create sensors for seven distinct proteins including the spike protein from SARS-CoV-2 and anti-SARS antibodies.
The identification of a lysosomal K+ channel complex—comprising AKT and the pore-forming TMEM175—provides insights into the mechanisms through which variants of the pore-forming protein affect the development of Parkinson’s disease.
An ultra-high-throughput multiplex protein–DNA binding assay is used to assess binding of 270 human transcription factors to 95,886 noncoding variants in the human genome, providing data to improve prediction of the effects of noncoding variants on transcription factor binding and thereby increase understanding of molecular pathways involved in diverse human traits and genetic diseases.
The insulin inhibitory receptor (inceptor) is identified as a negative regulator of insulin and IGF1 signalling that could be targeted for β-cell regeneration in treatments for diabetes.
The 2S–2P transitions in muonic helium-4 ions are measured using laser spectroscopy and used to obtain an α-particle charge-radius value five times more precise than that from electron scattering.
Multiplexed imaging of 3,660 chromosomal loci in individual mouse embryonic stem cells by DNA seqFISH+ with immunofluorescence of 17 chromatin marks and subnuclear structures reveals invariant organization of loci within individual cells, and heterogeneous and long-lived distinct combinatorial chromatin states in cellular subpopulations.
