Structural basis for the modulation of voltage-gated sodium channels by animal toxins
A detailed blueprint of how an ion channel interacts with neurotoxins at the molecular level could help guide the development of drugs for diseases caused by the aberrant transmission of electrical signals in muscles and neurons.
A Chinese–Australian team that included University of Queensland researchers used cryo-electron microscopy to create a high-resolution map of the voltage-gated sodium channel protein from cockroaches in complex with neurotoxins produced by three venomous animals — spiders, pufferfish and shellfish. Two of these toxins block the ion channel, while the other traps the channel in a particular conformation.
The structural insights gleaned from how the different toxins bind will be considerations as drug companies aim to target voltage-gated sodium channels for treating epilepsy, arrhythmia, pain and other conditions caused by defects in these channels.
- Science 362, eaau2596 (2018). doi: 10.1126/science.aau2596