A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling
- Journal:
- Nature Cell Biology
- Published:
- DOI:
- 10.1038/s41556-022-00866-3
- Affiliations:
- 12
- Authors:
- 23
Research Highlight
Mapping cells involved in blood cancers
© Sciepro/Science Photo Library/Getty Images
A single-cell atlas of a class of cells involved in some blood cancers has revealed new subgroups within this cell class.
Lymphomas are cancers of the blood that frequently originate in the lymph nodes. Most lymphomas remain uncurable.
A subset of cells known as non-hematopoietic cells (NHCs) are known to play important roles in the development of lymphomas, but how they do this is unclear.
Now, a team led by researchers from the University of Tsukuba in Japan has used single-cell RNA sequencing to create an atlas of more than 100,000 NHCs from 27 human samples.
Based on this atlas, the team was able to identified 30 subclusters, some of which hadn’t been recognized before.
This resource will help researchers to better understand the biology of lymphomas and also to discover new biomarkers.
References
- Nature Cell Biology 24, 565–578 (2022). doi: 10.1038/s41556-022-00866-3
| Institutions | Authors | Share |
|---|---|---|
| University of Tsukuba, Japan | 0.46 | |
| University of Tsukuba Hospital, University of Tsukuba, Japan | 0.23 | |
| Kameda Medical Center, Japan | 0.13 | |
| Kurume University, Japan | 0.09 | |
| Mito Medical Center, Japan | 0.04 | |
| NTT Medical Center Tokyo, Japan | 0.04 |