Single-cell multi-omics sequencing of human early embryos
- Journal:
- Nature Cell Biology
- Published:
- DOI:
- 10.1038/s41556-018-0123-2
- Affiliations:
- 11
- Authors:
- 14
Research Highlight
An epigenetic atlas of human embryos
© JUAN GARTNER/Science Photo Library/Getty
As a human embryo develops from a fertilized egg into a complex cluster of cells ready for implantation in the womb, the chemical tags adorning its DNA undergo a series of organizational changes.
A Peking University–led team has now profiled the nature of this epigenetic complexity down to the single-cell level in sperm, eggs and six stages of pre-implantation embryos. The detailed map of modifications to DNA and its spool-like coiling structures provides a vast informative resource for future mechanistic studies of early human development.
The researchers showed that DNA−protein complexes known as chromatin were most loosely packaged — allowing genes and regulatory elements to be more accessible and active — in eggs and in single-cell zygotes. Chemical alterations then prompted the chromatin to tighten its coils over the first few cell divisions before loosening again (and staying loose) after about four days of development.
References
- Nature Cell Biology 20, 847–858 (2018). doi: 10.1038/s41556-018-0123-2