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Despite their excellent macroscopic operational parameters, halide perovskites exhibit heterogeneity in materials properties at all lateral and vertical length scales. In this Review, we discuss the nature of heterogeneity in halide perovskites and assess the impact of these non-uniformities on their optoelectronic properties and how the heterogeneity may even be beneficial for device properties.
Materials with vanishingly small dielectric permittivity, known as epsilon-near-zero materials, enable strong ultrafast optical nonlinear responses within a sub-wavelength propagation length. This Review surveys the various observations of nonlinear phenomena in this class of materials.
High-entropy alloys have greatly expanded the compositional space for alloy design. In this Review, the authors discuss model high-entropy alloys with interesting properties, the physical mechanisms responsible for their behaviour and fruitful ways to probe and discover new materials in the vast compositional space that remains to be explored.
Electron beams in a transmission electron microscope can be used to manipulate matter atom-by-atom. This Review surveys the recent advances and discusses how the further development and integration of machine learning, theory, feedback and instrumentation will push the field forward.
Topological nanomaterials exhibit enhanced topological surface states and are thus promising for next-generation electronic devices and quantum computations. This Review discusses synthesis and transport results of topological nanomaterials, with a special focus on 1D topological superconductivity realized using topological insulator nanowires.
The first clinical success of immunotherapeutics for cancer treatment and the appreciation that tissue regeneration can be greatly improved by precisely and locally modulating the immune response are evidence that immunotherapy is poised to revolutionize the way we treat disease.
Supramolecular gels comprise low-molecular weight gelators that assemble by non-covalent interactions. In this Review, a range of fabrication methods, as well as strategies for shaping, structuring and patterning supramolecular gels are discussed.
European accelerator-based X-ray facilities came together in 2017 in a consortium that will use their combined expertise to accelerate discoveries, secure funding and guide policy. A year and a half later, the chair of the consortium Helmut Dosch reflects on the ambition and opportunities of this type of cooperation.
Type 1 diabetes is an autoimmune disease that causes the destruction of pancreatic β-cells, which results in an insulin deficiency. In this Review, the authors discuss immunomodulatory biomaterials for β-cell replacement and for the induction of tolerogenic immune responses to prevent, delay or reverse the disease.
Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.
Cancer nanomedicine in combination with immunotherapies offers the possibility to amplify antitumour immune responses and to sensitize tumours to immunotherapies. In this Review, the authors discuss combination immunotherapy based on nanoparticle platforms designed for chemotherapy, photothermal therapy, photodynamic therapy, radiotherapy and gene therapy.
Materials research is poised to play a pivotal role in addressing the grand challenges faced by society, from engineering better medicines to providing accessible clean water and renewable energy. However, complex problems require diverse teams. Therefore, there is an urgent need to address the diversity gap in materials science and engineering, especially for women.
Macroscale delivery devices can be used to manipulate innate and adaptive immune responses. In this Review, the authors highlight important cellular targets of immunotherapies in tissue repair and cancer and discuss macroscale biomaterials strategies for therapeutic immunomodulation.
Georg Bednorz, together with Karl Alexander Müller, discovered high-temperature superconductivity (HTS) in ceramics, for which they were awarded the Nobel Prize in Physics in 1987. Christine Horejs talks to Georg Bednorz about the successes and challenges of his research on HTS, applications of HTS materials, and the key ingredients for scientific discoveries.
