Research articles

In this study Stubbs et al. find that neuroimaging neuroimaging abnormalities across substance use disorders map to a common brain network that is similar across imaging modalities and substance use categories.

In this exposome-wide association study using the FinnTwin12 cohort, Wang et al. show that familial component of social exposure has a significant association with depressive symptoms in late adolescence and early adulthood.

The authors conducted a systematic review and meta-analysis to identify predictors of placebo response in repetitive transcranial magnetic stimulation treatment for depression.

In this retrospective study, Wen and colleagues used data from the Adolescent Brain and Cognitive Development cohort study to investigate the neurobiological, psychological and social characteristics that are associated with self-injurious thoughts and behaviours transitions in children.

Zhao et al. use UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.

The authors used region of interest (ROI)-to-ROI analysis to investigate functional connectivity patterns in patients with post-traumatic stress disorder (PTSD) and its dissociative subtype compared with healthy controls.

In this cross-sectional study, Blain and colleagues show that sensitivity to diverse visual, cognitive and social, putatively intrinsic rewarding stimuli is partly domain general and is linked to affective aspects of mental health unlike sensitivity to monetary rewards.

Using a large dataset of approximately 300,000 individuals from the UK Biobank, Zhang, Deng, Li et al. investigated the relationships between personality traits, brain health, inflammation and metabolites.

Catarino et al. used real-world data from the UK healthcare system to perform an economic evaluation comparing the cost-effectiveness of in-person and internet-delivered cognitive behavioral therapy for mood and anxiety disorders.

In this Article, Singh and coauthors put forth a new machine-learning approach to evaluate inclusion and exclusion criteria from psychiatry abstracts to automate systematic reviews.

The authors use multimodal magnetic resonance imaging to investigate microstructural alterations and functional deficits in white matter in a multi-disorder sample (patients with schizophrenia, major depressive disorder, bipolar disorder or obsessive–compulsive disorder) when compared with a healthy control sample.

Using an integrated analysis on three independent large human datasets, Wang et al. map macroscale dysconnectivity in schizophrenia onto layer- and cell-type-specific microscale alterations. The authors identify different alterations of corticocortical and corticostriatal connectivity in schizophrenia and their relationship to different symptom dimensions and functional domains.

Using meta-analytic techniques, authors report patterns of aberrant functional brain associated with differences in neurophysiology and cognitive and behavioral regulatory mechanisms in men diagnosed with pedophilic disorder to elucidate potential mechanistic and pharmacological interventions.

In a sample of children and adolescents aged 11–16 years old, authors used plasma-based proteomic techniques to identify biomarkers associated with risk for developing a mental health disorder.

Hu et al. performed a network analysis to investigate the relationship between a two-factor model of negative symptoms, social functioning and other psychopathological symptoms in a transdiagnostic sample of patients with major depression, schizophrenia and bipolar disorder.

Using a sample of over 4,900 adolescents, Westwater et al. show that genetic risk for anorexia nervosa and high body mass have distinct associations with brain structure and psychopathology symptoms related to eating disorders.

Cocchi and coauthors report that continuous theta burst stimulation of the frontal pole shows no difference from sham in reducing symptoms of obsessive-compulsive disorder or frontostriatal connectivity.

In this analysis of data from the Healthy Minds Study of over 200,000 college students in the United States, the authors found greater levels of depressive and anxiety symptoms and sexual violence and assaults experienced by gender and sexual minorities during the pandemic. These findings reinforce the disproportionate and heightened mental health and sexual violence risks for gender and sexual minority youth and the need to increase on-campus safety and crisis intervention.

Galante et al. performed a systematic review and meta-analysis using individual participant data from randomized controlled trials evaluating mindfulness-based programs for adult mental health promotion in non-clinical settings.

In this secondary analysis of a clinical trial exploring the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE) versus supportive group psychotherapy for reducing post-traumatic stress disorder (PTSD) symptoms in patients with chronic pain receiving opioid treatment, the authors demonstrate that increased cognitive reappraisal mediated reduced PTSD symptoms and opioid misuse after the MORE intervention.