Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Panayiotou et al. performed a panel network analysis to investigate the relationship between time spent on social media and mental health in a large cohort of UK adolescents.

Galante et al. performed a systematic review and meta-analysis using individual participant data from randomized controlled trials evaluating mindfulness-based programs for adult mental health promotion in non-clinical settings.

Catarino et al. used real-world data from the UK healthcare system to perform an economic evaluation comparing the cost-effectiveness of in-person and internet-delivered cognitive behavioral therapy for mood and anxiety disorders.

In this pilot study, the authors detected specific brain regions that can be precisely targeted with transcranial magnetic stimulation to influence heart rate. The heart–brain coupling might serve as a readout to identify optimal individualized transcranial magnetic stimulation targets for depression.

The authors report data from the emergency department AURORA study to characterize resilience in more detail than the absence of psychopathology after trauma.

This study identifies a set of risk factors that fully mediate and uniquely contribute to the relationship between sex assigned at birth and posttraumatic stress disorder severity.

The authors conducted a systematic review to examine whether pharmacogenetic testing affects clinical or economic outcomes in patients taking antipsychotic medication.

Using stereotactic electroencephalography, the authors identified differential amygdala activation in response to emotional faces in participants with treatment-resistant depression compared with non-depressed participants with epilepsy, suggesting possible deep brain stimulation targets.

Reporting, discussing and interpreting sex differences in clinical and biomedical research has become a more complicated task in recent years, but necessarily so. Achieving clarity around what constitutes sex and what is associated with gender provides few conclusive answers and far more questions. As cogently expressed by Beans Velocci, a historian of sex and science, in a recent piece in Cell on sex as a scientific category, “…because it is so many things at once, all we can say for sure about what sex is is what a given scientist does with it” (B. Velocci, Cell 187, 1343–1346; 2024).

In this cross-species translational study, the authors look at the longitudinal consequences of stress during adolescent development on HPA function and postpartum behaviors in mice and in humans and suggest that glucocorticoid receptor antagonists may serve as a potential treatment for postpartum depression.

In this Review the authors address the intersection between mental illness and homelessness in high-income countries, and propose policy and practice priorities to reduce homelessness and to improve health outcomes.

In this article, the authors demonstrate that haloperidol D2/D3 dopamine antagonism contributes to flexibility in beliefs about the intentions of social partners during a sharing game.