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Immunomagnetic cell sorting implemented in a microfluidic chip can perform loss-of-function CRISPR–Cas9-mediated phenotypic screening at higher throughput than fluorescence-activated cell sorting.
The overexpression of β-catenin and the transcription factor Gata4 in skin fibroblasts induces these cells to secrete reparative exosomes, as shown in mice models of myocardial infarction and Duchenne muscular dystrophy.
A reconfigurable microfluidic cell-culture system that facilitates the assembly of 3D tissue models by stacking layers containing preconditioned microenvironments enables the modelling of the spatiotemporal dynamics of paracrine signalling.
Bioresorbable photonic devices for the spectroscopic characterization of tissues and biofluids can continuously monitor cerebral temperature, oxygenation and neural activity in the brains of freely moving mice before they are fully resorbed.
A sprayable dynamically crosslinked supramolecular polymer–nanoparticle hydrogel that robustly adheres to tissue reduces the severity of cardiac adhesions in rats and sheep.
The polymer encapsulation of the monoclonal antibody rituximab and the ligand-mediated targeting of metastases in the central nervous system significantly improve antitumour efficacy in mouse models of metastatic non-Hodgkin lymphoma.
Smartphone-controlled soft optofluidic probes with replaceable plug-like drug cartridges enable chronic in vivo pharmacology and optogenetics for the selective wireless manipulation of brain circuits in rodents.
Dextran nanoparticles loaded with a chemotherapeutic agent and bound to phages that eliminate a pro-tumoural gut bacterium and promote the growth of anticancer-compound-producing bacteria boost chemotherapy responses in mouse models of colorectal cancer.
A parameter derived from the collective order of monolayers of corneal endothelial cells makes for a non-invasive quantitative biomarker of the quality of the cells in culture and of the long-term prognosis of corneal restoration in patients.
Orthologous therapeutic proteins can elude the adaptive immune system and allow for effective repeated dosing, as shown for CRISPR gene editing with orthologues of adeno-associated viral capsids and of the Cas9 protein.
Barcodes based on tetrahedral DNA nanostructures enable the multiplexed profiling of the subcellular expression and distribution of proteins in cells from patient samples.
In a 3D model of breast cancer, a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1.
The detection of small tumours with PET is significantly enhanced by temporal integration of the imaging signals, triggered by the acidic milieu of cancers, from pH-sensitive positron-emitting polycationic polymers.
DNA aptamers that specifically bind to the T-cell marker CD8 and can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for chimeric antigen receptor T-cell therapies.
A fast in vitro model of the formation of bone-like nodules, enabled by the retinoic-acid-mediated induction of the osteogenic differentiation of patient-derived induced pluripotent stem cells, recapitulates the osteogenesis-imperfecta phenotype.
Engineering T cells for adoptive cell transfer, via the orthotopic replacement of both T-cell receptor chains, preserves the dynamics of T-cell-receptor expression as well as physiological T-cell function.
A microphysiological cartilage on a chip that enables the application of strain-controlled compression recapitulates the mechanical factors involved in the pathogenesis of osteoarthritis.