Review Articles

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  • This Review examines classical methods for the preservation of mammalian biospecimens and the associated mechanisms of cryoinjury and discusses how the methods’ applicability limitations are being addressed.

    • Haishui Huang
    • Xiaoming He
    • Martin L. Yarmush
    Review Article
  • This Review summarizes the rapidly expanding toolbox of assays for CRISPR-based diagnostics and highlights their point-of-care applications.

    • Michael M. Kaminski
    • Omar O. Abudayyeh
    • James J. Collins
    Review Article
  • This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.

    • Ava M. Vargason
    • Aaron C. Anselmo
    • Samir Mitragotri
    Review Article
  • This Review Article discusses progress in the development of miniaturized and ultralightweight devices for neuroengineering that are wireless, battery-free and fully implantable.

    • Sang Min Won
    • Le Cai
    • John A. Rogers
    Review Article
  • This Review discusses methods for the creation of microphysiological human brain models that recapitulate aspects of major neurological disorders.

    • Hsih-Yin Tan
    • Hansang Cho
    • Luke P. Lee
    Review Article
  • This Review discusses non-invasive and invasive technologies for conveying artificial sensory feedback through bionic hands.

    • Sliman J. Bensmaia
    • Dustin J. Tyler
    • Silvestro Micera
    Review Article
  • This Review summarizes progress in the development of engineering strategies employed in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches.

    • Emma S. Gargus
    • Hunter B. Rogers
    • Teresa K. Woodruff
    Review Article
  • This Review summarizes the development of optoacoustic imaging with acoustic resolution and wide-bandwidth ultrasound detection, and the applicability of this mesoscopic imaging modality in the label-free visualization of tissue pathophysiology.

    • Murad Omar
    • Juan Aguirre
    • Vasilis Ntziachristos
    Review Article
  • This Review discusses the factors that affect the phenotypes of mesenchymal stromal cells, and the need for standardized assays that provide quality assurance for clinical uses of the cells.

    • James Q. Yin
    • Jun Zhu
    • James A. Ankrum
    Review Article
  • This Review summarizes the medical applications of artificial intelligence, and its economic, legal and social implications for healthcare.

    • Kun-Hsing Yu
    • Andrew L. Beam
    • Isaac S. Kohane
    Review Article
  • This Review discusses the manufacturing of cell products for clinically advanced cell therapies, and highlights potential manufacturing bottlenecks and solutions towards the cost-effective commercialization of the therapies.

    • Ayesha Aijaz
    • Matthew Li
    • Biju Parekkadan
    Review Article
  • This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.

    • Louai Labanieh
    • Robbie G. Majzner
    • Crystal L. Mackall
    Review Article
  • This Review discusses technology for the isolation and phenotypic profiling of circulating tumour cells from blood for the identification of those with high metastatic potential as well as requirements for clinical applications of the cells.

    • Mahla Poudineh
    • Edward H. Sargent
    • Shana O. Kelley
    Review Article
  • This Review discusses the role of glia as an effector of the performance and integration of devices implanted in the brain, and the implications of this for device development.

    • Joseph W. Salatino
    • Kip A. Ludwig
    • Erin K. Purcell
    Review Article
  • This Review discusses imaging approaches that benefit from the combination of signals and modalities to enhance patient diagnosis and the monitoring of therapy.

    • Kathrin Heinzmann
    • Lukas M. Carter
    • Eric O. Aboagye
    Review Article
  • This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.

    • Brian A. Aguado
    • Grace G. Bushnell
    • Lonnie D. Shea
    Review Article
  • This Review covers recent progress on near-infrared fluorescence imaging for preclinical animal studies and clinical diagnostics and interventions.

    • Guosong Hong
    • Alexander L. Antaris
    • Hongjie Dai
    Review Article
  • This Review provides a broad account of the applications of light in imaging, diagnosis, therapy and surgery, and discusses the promise of emerging light-based technologies.

    • Seok Hyun Yun
    • Sheldon J. J. Kwok
    Review Article