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This Perspective discusses the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease.
The inability to precisely manipulate mammalian mitochondrial DNA has stalled our understanding of mitochondrial biology and the generation of cellular and animal models in which to study it. DNA base editing technologies have enabled the generation of a library of mitochondrial base editors that precisely ablate every protein-coding gene in the mouse mitochondrial genome.
Cytotoxic CAR T cells derived from human induced pluripotent stem cells can be genetically engineered for enhanced proliferation and persistency in solid tumours.
A contractile soft robotic actuator implanted above the diaphragm in pigs with respiratory insufficiency restores the animals’ respiratory performance.
A library of double-stranded-DNA deaminase-derived cytosine base editors allows for the precise ablation of every mtDNA protein-coding gene in the mouse mitochondrial genome.
Systemically administered piezoelectric nanoparticles producing nitric oxide and generating direct current under high-intensity focused ultrasound can be used to stimulate deep tissue in the brain, as shown in a mouse model of Parkinson’s disease.
Water exchange through the transmembrane channel aquaporin-4 can be measured by conventional dynamic-contrast-enhanced magnetic resonance imaging and is a sensitive biomarker of the proliferation of gliomas and their resistance to chemotherapy.
Comparisons of neural recordings across time, across subsets of neurons and across individuals requires the alignment of low-dimensional latent representations.
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.
An anti-CD98 antibody with pH-dependent binding elicits tumour-specific Fc-mediated anti-tumour activity in multiple xenograft and syngeneic tumour models established in CD98-humanized mice.
Neuroectodermal cells produced via the direct reprogramming of human astrocytes can be induced to form spinal-cord organoids with functional neurons specific to the dorsal and ventral domains.
Transmembrane water-efflux rate is a sensitive biomarker of the expression of aquaporin-4, and can be measured via conventional dynamic-contrast-enhanced magnetic resonance imaging, as shown in animals and in patients with gliomas.
Graph deep learning applied to multiplexed immunofluorescence data from tumour microenvironments reveals spatial cellular structures that are indicative of cancer prognosis.
A graph neural network that leverages spatial protein profiles in tissue specimens to model tumour microenvironments as local subgraphs captures distinctive cellular interactions associated with differential clinical outcomes.
Genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions can make them surrogate receptor agonists with longer half-lives in circulation and enhanced penetration of the blood–brain barrier.
Off-the-shelf microphones and earbud components connected to a smartphone can be as effective as an expensive clinical-grade device at measuring otoacoustic emissions to screen for hearing loss.