Graph deep learning applied to multiplexed immunofluorescence data from tumour microenvironments reveals spatial cellular structures that are indicative of cancer prognosis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Goltsev, Y. et al. Deep profiling of mouse splenic architecture with CODEX multiplexed imaging. Cell 174, 968–981.e15 (2018). This paper presents CODEX, the multiplexed immunofluorescence imaging method used in this work.
Schürch, C. M. et al. Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front. Cell 182, 1341–1359.e19 (2020); erratum 183, 838 (2020). This paper presents the cellular neighbourhood method for analysing multiplexed immunofluorescence imaging.
Argiris, A., Karamouzis, M. V., Raben, D. & Ferris, R. L. Head and neck cancer. Lancet 371, 1695–1709 (2008). A review article that presents an overview of head-and-neck cancer.
Blise, K. E., Sivagnanam, S., Banik, G. L., Coussens, L. M. & Goecks, J. Single-cell spatial architectures associated with clinical outcome in head and neck squamous cell carcinoma. NPJ Precis. Oncol. 6, 10 (2022). This paper discusses tumour–immune cell spatial compartmentalization in head-and-neck squamous cell carcinoma.
Trellakis, S. et al. Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease. Int. J. Cancer 129, 2183–2193 (2011). This paper discusses the role of tumour-infiltrating polymorphonuclear granulocytes in head-and-neck squamous cell carcinoma.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Wu, Z. et al. Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00951-w (2022).
Rights and permissions
About this article
Cite this article
Learning spatial cellular motifs predictive of the responses of patients to cancer treatments. Nat. Biomed. Eng 6, 1328–1329 (2022). https://doi.org/10.1038/s41551-022-00958-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-022-00958-3