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The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.
Biomarkers of health and disease in urine and stool can be longitudinally tracked with a ‘smart’ toilet incorporating biometric identification, pressure and motion sensors, urinalysis strips and a uroflowmeter.
The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.
The selection of double-bridged peptides via in vitro phage display yields constrained cyclic peptides optimized for high therapeutic specificity and for stability against gastrointestinal proteases.
The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
A robotic culture system for the high-throughput analysis of drug transport in porcine gastrointestinal tissue explants accurately predicts the absorption of orally taken drugs in the human gut.
Enhancing the binding of growth factors to heparan sulfate proteoglycans in the extracellular matrix and on cell surfaces improves wound healing and bone regeneration in mice.
Structural and functional changes following infarction in a human heart can be modelled with human cardiac organoids set in a hypoxic gradient and stimulated with the neurotransmitter noradrenaline.
The conversion of a deuterated substrate into cellular metabolites in vivo can be quantified via decreases in the proton nuclear magnetic resonance signals of these metabolites.
The photothermal and magnetothermal properties of carbon-coated iron cobalt nanoparticles with a polymer shell make them sensitive tracers for in vivo magnetic particle imaging, magnetic resonance imaging and photoacoustic imaging.
An optical-imaging instrument that integrates multispectral imaging for the detection of fluorescence in the first and second near-infrared windows aids the surgical resection of liver tumours in patients.
The detection of small tumours with positron emission tomography is significantly enhanced by 64Cu-labelled polycationic polymers sensitive to the acidic pH of tumours.
Epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient can be detected via a fluorescently labelled inhibitor of the DNA-repair enzyme poly(ADP-ribose) polymerase 1.
Nanoscale strains in the intact whole joints of young, old and osteoarthritic mice can be resolved ex vivo via synchrotron X-ray tomography when combined with nanometrically precise mechanical loading.
Wireless and leadless millimetre-scale implantable pulse generators, powered and controlled by ultrasonic links, enable the electrical stimulation of neural pathways in anaesthetized rats.
An array of 4,096 nanoelectrodes can record and stimulate intracellular action potentials, as well as excitatory and inhibitory post-synaptic potentials, from thousands of connected mammalian neurons in culture.
