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Translating a fluorescent DNA-repair inhibitor

Nature Biomedical Engineering volume 4, pages 247–249 (2020)Cite this article

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Epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient can be detected via a fluorescently labelled inhibitor of the DNA-repair enzyme poly(ADP-ribose) polymerase 1.

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Fig. 1: Steps for the clinical validation and for the assessment of the clinical value of the optical contrast agents panitumumab-IRDye800CW (top) and PARPi-FL (bottom).

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Authors and Affiliations

  1. Department of Otolaryngology — Head and Neck Surgery, Stanford University, Stanford, CA, USA

    Guolan Lu & Eben L. Rosenthal

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  1. Guolan Lu
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  2. Eben L. Rosenthal
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Correspondence to Eben L. Rosenthal.

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Lu, G., Rosenthal, E.L. Translating a fluorescent DNA-repair inhibitor. Nat Biomed Eng 4, 247–249 (2020). https://doi.org/10.1038/s41551-020-0537-6

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