The selection of double-bridged peptides via in vitro phage display yields constrained cyclic peptides optimized for high therapeutic specificity and for stability against gastrointestinal proteases.
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D.B. consults for pharmaceutical companies working on oral peptide delivery, and in the past five years has received research grants from Sanofi, Jazz Pharmaceuticals, Nuritas Ltd. and Gatefossé Ltd.
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Brayden, D.J. Evolving peptides for oral intake. Nat Biomed Eng 4, 487–488 (2020). https://doi.org/10.1038/s41551-020-0559-0
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DOI: https://doi.org/10.1038/s41551-020-0559-0