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A microfluidics-based sequencing method that profiles genome-wide DNA methylation using only sub-nanogram quantities of DNA finds distinct DNA methylome patterns in glial and neuronal cell nuclei from mouse brains treated with an antipsychotic drug.
A new chemically defined culture medium for the long-term culture of human pluripotent stem cells uses only three chemical compounds and a lower number of recombinant proteins than used in commercially available media.
An ultrathin, needle-shaped piezoelectric microsystem that can be injected or mounted onto conventional biopsy needles measures variations in tissue modulus in real time and can thus be used to distinguish abnormal from healthy tissue.
Deep learning predicts, from retinal images, cardiovascular risk factors—such as smoking status, blood pressure and age—not previously thought to be present or quantifiable in these images.
A compact, self-contained device bearing an array of microneedles collects 100 μl of blood at the push of a button, and is more convenient and less painful than a fingerstick and venepuncture.
Cells engineered to produce an analgesic in response to spearmint aroma and implanted in mouse models of chronic pain reduce the pain-associated behaviour after oral intake of spearmint essential oil with no adverse effects.
A system that combines positron emission tomography, computed tomography and ultrafast ultrasound allows for simultaneous multi-parametric imaging in animal models.
A microtechnology involving force sensors embedded in elastomers for cell culture enables the high-throughput measurement of single-cell force generation from contractile cells in a scalable and highly parallelized manner.
The slow release of pro-survival peptide analogues crosslinked to an injectable collagen–dendrimer biomaterial significantly prolongs the engraftment and survival of transplanted stem cells in mouse models of ischaemic injury.
Nanoparticles carrying an antibiotic and conjugated with a peptide identified via phage display that binds specifically to Staphylococcus aureus effectively suppress staphylococcal infections in vivo.
Engineered commensal microbes that transform natural compounds present in cruciferous vegetables into an anticancer molecule prevent carcinogenesis and promote the regression of colorectal cancer in mice fed with the microbes and the vegetables.
A cloud-based machine-learning software that scores individual guide–target pairs and provides an overall summary score for a given guide that outperforms competing algorithms for the prediction of CRISPR–Cas9 off-target effects.
The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.
A patient-specific soft cardiovascular occluder made via three-dimensional printing and static moulding of an inflatable polymer balloon on the basis of data derived from computed tomography scans of a large animal is implanted in the same animal.
A biodegradable probe made of dextran and a urea-based targeting ligand for prostate-specific membrane antigen enables targeted magnetic resonance imaging of tumours expressing the receptor in a xenograft mouse model of prostate cancer.
A computational approach that uses the statistics of movement to find a mapping between neural activity and motor variables decodes the intended movements of monkeys with performance comparable to that of supervised methods.
A slide-free, inexpensive and non-destructive microscopy technique rapidly provides high-resolution histology images that resemble those obtained from conventional haematoxylin-and-eosin-stained specimens.
An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in mice after myocardial infarction.
A model accounting for the properties of the local chromatin environment predicts the modulation of patterns in gene expression and helps screen for chemotherapeutic adjuvants that lead to an enhanced therapeutic response in cancer cells.