Announcements

  • Dementia conference in Africa

    The first-ever Nature Dementia conference to be held on the African continent is taking place September 11th - 12th, 2024 in Nairobi, Kenya. The event will be convened by Nature Conferences, the Davos Alzheimer's Collaborative, and Aga Khan University.

  • Nature awards microbiome accelerator

    The Accelerator will identify microbiome research with the potential to transform human health outcomes. Four carefully chosen applicants will be awarded $10,000 and gain entry to our immersive residential programme that provides the training/mentorship, and connections to translate groundbreaking research for maximum impact. Deadline for applications is 24 June 2024.

  • Issue cover featuring an artistic depicting of a human brain with different parts in the share of jigsaw puzzle pieces

    Nature Aging published a special issue on the transforming landscape of dementia research. This Focus issue brings together a selection of Reviews, Perspectives and Comments on the most recent advances in our understanding of Alzheimer’s disease and other dementias, as well as the challenges in diagnosis, prevention and treatment of these diseases.

Nature Aging is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

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  • This comprehensive resource offers new insights into how different types of cell and tissue change with age in C. elegans and unveils the distinctive anti-aging effects of various pro-longevity strategies in a cell-type-specific manner.

    • Shihong Max Gao
    • Yanyan Qi
    • Meng C. Wang
    ResourceOpen Access
  • Katsuumi, Shimizu, Suda et al. report that SGLT2 inhibition reduces the senescence burden and alleviates aging traits in mice. The authors demonstrate an indirect mechanism of senescent cell removal, through enhancing immunosurveillance.

    • Goro Katsuumi
    • Ippei Shimizu
    • Tohru Minamino
    LetterOpen Access
  • The authors developed a proteomic risk score that improved the prediction of hip fractures in three validation cohorts analyzed by two different proteomic platforms. This risk score constitutes a new tool to stratify patients by hip fracture risk.

    • Thomas R. Austin
    • Maria Nethander
    • Claes Ohlsson
    LetterOpen Access
  • Liu et al. identify downregulation of DDX5, an RNA helicase, in the cartilage of patients and mouse model of osteoarthritis. Targeted upregulation of DDX5 in mouse chondrocytes inhibits hyaline cartilage fibrosis and degradation via pre-mRNA splicing and G4 unwinding, a potential therapeutic strategy against osteoarthritis.

    • Qianqian Liu
    • Mingrui Han
    • Yang Sun
    ArticleOpen Access
  • Tong et al. construct simulations using DNA methylation data to quantify what proportion of the predictive accuracy of epigenetic clocks could be explained by stochastic methylation changes, suggesting that stochasticity contributes more toward the accuracy of chronological rather than biological age predictions.

    • Huige Tong
    • Varun B. Dwaraka
    • Andrew E. Teschendorff
    AnalysisOpen Access
    • Small extracellular vesicles (sEVs) derived from the blood of young mice are shown to have the potential to extend lifespan and rejuvenate physiological functions in aged mice. Mechanistically, microRNA (miRNA) cargoes within these sEVs alleviated age-related dysfunction by promoting the expression of PGC1α and enhancing mitochondrial energy metabolism.

      Research Briefing
    • A study in Nature Aging on electronic health records from 1.7 million people in New Zealand reveals that most patients with dementia have a history of hospital-treated infection. In a dementia-free population, individuals with a severe infection were at a threefold-higher risk of dementia even 25 years later.

      • Mika Kivimäki
      • Keenan A. Walker
      News & Views
    • Aging-related DNA methylation changes are numerous. Their precise measurement has opened new avenues to explore aging-related disease pathology, including the construction of chronological and biological age predictors (termed DNA methylation ‘clocks’). Three studies investigate the substantial stochastic contribution to these epigenetic changes and further our understanding of aging biology, as well as of these predictors.

      • Christopher G. Bell
      News & Views
    • Zou and colleagues design and analyze a health education program that targeted college students (who were grandchildren) to encourage older persons who had already had their first COVID-19 vaccine dose to receive a booster. The program increased the uptake of booster doses, which highlights the fact that family ties can have positive roles in the context of a pandemic.

      • Bruno Arpino
      News & Views
    • Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.

      • Ariane Zamoner
      • Pedro Fontes Oliveira
      • Marco G. Alves
      News & Views
A group of 3D cancer cells emerging

Cancer and aging

This cross-journal Collection invites original research that explicitly explores the role of aging in cancer and vice versa, from the bench to the bedside.
Collection
Open for submissions

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