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In this issue, the paper by Lin et al describes how hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality. The cover shows a single case of chondrosarcoma with mixed histology (see December 2018 issue, p1834).
In this era of minimally-invasive procedures for diagnosis, prognosis and treatment decisions, pathologists are asked to make more specific diagnoses from smaller samples. We asked top experts in their fields to discuss their strategies and most practical approaches to maximizing the information gained from limited specimens.