George F Murphy

Welcome to Laboratory Investigation

Advancing the understanding of human and experimental disease

Latest Issue

Laboratory Investigation is a Transformative Journal; authors can publish using the traditional publishing route OR Open Access.
Our Open Access option complies with funder and institutional requirements.

Latest Research

  • Article |

    PLODs play important roles in cancer progression. In silico analysis of PLOD expression in ovarian cancer was performed. PLOD-enriched pathways and related genes were validated by immunohistochemistry in OvCa tissue blocks and in vivo xenograft murine models. PLODs are generally overexpressed in OvCa and each PLOD may be functionally non-redundant.

    • Ting Guo
    • , Chao Gu
    • , Bin Li
    •  & Congjian Xu
  • Article |

    Real-time lipid patterns can identify liver tumors and their inter-tumor and intra-tumor heterogeneity. Ceramides and related sphingolipids are a common feature of necrotic tumors and can characterize the tumor phenotype based on metabolic shifts relevant for cell death pathways. Lipid patterns have the potential to improve clinical decision-making in the near future.

    • Pierre-Maxence Vaysse
    • , Heike I. Grabsch
    • , Mari F. C. M. van den Hout
    • , Marc H. A. Bemelmans
    • , Ron M. A. Heeren
    • , Steven W. M. Olde Damink
    •  & Tiffany Porta Siegel
  • Article |

    Using approaches involving chimeric mice and macrophage-adipocyte cocultures, the authors demonstrate that PFKFB3 disruption only in hematopoietic cells exacerbates the severity of diet-induced adipose tissue inflammation and systemic insulin resistance. Mechanistically, macrophage factors generated in response to PFKFB3 disruption act to enhance adipocyte proinflammatory responses and impair adipocyte insulin signaling.

    • Bilian Zhu
    • , Xin Guo
    • , Hang Xu
    • , Boxiong Jiang
    • , Honggui Li
    • , Yina Wang
    • , Qiongli Yin
    • , Tianhao Zhou
    • , James J. Cai
    • , Shannon Glaser
    • , Fanyin Meng
    • , Heather Francis
    • , Gianfranco Alpini
    •  & Chaodong Wu
  • Review Article |

    Data processing and learning has become a spearhead for the advancement of medicine. Computational pathology is burgeoning subspecialty that promises a better-integrated solution to whole-slide images, multi-omics data and clinical informatics as innovative approach for patient care. This review describes clinical perspectives and discusses the statistical methods, clinical applications, potential obstacles, and future directions of computational pathology.

    • Miao Cui
    •  & David Y. Zhang
  • Article |

    Recent studies highlight a prominent role of human lung pericytes in lung diseases. However, human lung pericytes usually stop growth within ten passages. This study successfully established an immortalized human lung pericyte cell line, which exhibited sustained proliferation, retained pericyte characteristics and function, is a promising tool for in vitro pericyte studies.

    • Pengfei Li
    • , Yan Wu
    • , Andrew J. Goodwin
    • , Perry V. Halushka
    • , Carole L. Wilson
    • , Lynn M. Schnapp
    •  & Hongkuan Fan
  • Article |

    In this study, the authors reveal that the hypoxic microenvironment stimulates glioma to generate miR-1246- and miR-10b-5p-rich exosomes, which are delivered to normoxic glioma cells to promote their migration and invasion by targeting FRK and TFAP2A respectively. Treatment targeting the exosomes and microRNAs may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.

    • Mingyu Qian
    • , Zihang Chen
    • , Xiaofan Guo
    • , Shaobo Wang
    • , Zongpu Zhang
    • , Wei Qiu
    • , Yanhua Qi
    • , Shouji Zhang
    • , Jianye Xu
    • , Rongrong Zhao
    • , Hao Xue
    •  & Gang Li

News & Comment

Supplement

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world
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