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A strategic and statistically based experimental design is a key component of Reduction, and the backbone of reproducible research. Design basics consist of formal structuring of input variables and clearly defined experimental units. Formal designs can evaluate two or more input factors simultaneously, identify and prioritise the most important inputs, and identify interactions where most discovery occurs.
IACUCs need to ensure the application of the 3Rs, while allowing researchers to conduct their work with reasonable flexibility. We invited experts from the University of Notre Dame (Eric Felde) and Northwestern University (Stefanie Bittner), along with USDA and OLAW representatives (Louis DiVincenti and Axel Wolff) to respond to a challenging situation at Great Eastern University.
The authors defined rat microbial biogeography by re-analyzing publicly available RNA sequencing data from 11 organs of juvenile, adolescent, adult and aged Fisher 344 rats.
The study introduces an open-source, customizable 3D printable design for rodent conditioning for magnetic resonance imaging and other imaging modalities. The design is easy to use and can be applied to both anesthetized and awake mice, and anesthetized rats.