Hypoxia and metabolism

Throughout 2008, a series of specially commissioned articles that examine hypoxia and metabolism in tumour biology will be published in Nature Reviews Cancer. Although hypoxia is not a new phenomenon, we now have a much greater understanding of the molecular links between hypoxic conditions and tumour development. Apart from driving angiogenesis, hypoxia is also linked with changes in cellular metabolism, an area that has become a hot topic in cancer research. A greater understanding of these closely related tumorigenic changes should prove fruitful in the pursuit of more effective cancer drugs.

Index

2008

December 2008 Vol 8 No 12

The impact of O2 availability on human cancer

Jessica A. Bertout, Shetal A. Patel & M. Celeste Simon

doi:10.1038/nrc2540

November 2008 Vol 8 No 11

Hypoxia signalling through mTOR and the unfolded protein response in cancer

Bradly G. Wouters & Marianne Koritzinsky

doi:10.1038/nrc2501

November 2008 Vol 8 No 11

The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

William G. Kaelin Jr

doi:10.1038/nrc2502

September 2008 Vol 8 No 9

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Nicholas C. Denko

doi:10.1038/nrc2468

June 2008 Vol 8 No 6

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Mark W. Dewhirst, Yiting Cao & Benjamin Moeller

doi:10.1038/nrc2397

March 2008 Vol 8 No 3

Hypoxia, DNA repair and genetic instability

Robert G. Bristow & Richard P. Hill

doi:10.1038/nrc2344

January 2008 Vol 8 No 1

A microenvironmental model of carcinogenesis

Robert A. Gatenby & Robert J. Gillies

doi:10.1038/nrc2255

January 2008 Vol 8 No 1

The interplay between MYC and HIF in cancer

Chi V. Dang, Jung-whan Kim, Ping Gao & Jason Yustein

doi:10.1038/nrc2274

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