Spatial transcriptomics of pulmonary fibrosis
Spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with disease.
Spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with disease.
We identify that signal-dependent and ligand-dependent enhancer activation programs require release of a shared enhancer RNA (eRNA) transcription checkpoint. Further mechanistic evidence reveals signal-dependent activation of P-TEFb on enhancers, which licenses the enhancer transcriptional program by overcoming pausing of transcription and promoting eRNA elongation.