Nature Reviews Molecular Cell Biology | Review
The 3D genome
The 3D configurations of the genome and the nucleus are complex, dynamic and crucial for the proper control of gene expression and physiology. In the past few years, technological advances in the investigation of higher-order chromatin structure and function — pioneered by chromosome conformation capture methods and by improved microscopy techniques — revealed how the organization of the genome is interconnected with nuclear architecture and can vary between cell types and during cell differentiation and development. Not surprisingly, mutations that alter nuclear architecture cause many human conditions and diseases, which have shed light on the molecular mechanisms that underlie the connections between nuclear organization and physiology.
This collection includes recent Reviews, Research articles and Protocols from across the Nature group of journals — it showcases both the latest advances in the methodologies used to study genome organization and our emerging understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease.
The content of this collection has been chosen by the editors of Nature Reviews Molecular Cell Biology.