Nature Reviews Molecular Cell Biology
Volume 10, No 7 July 2009
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2008 ISI Impact Factor 35.423(*Source of Impact Factor data)
Current Issue
Review
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl & Darren Gilmour
The collective migration of cells as cohesive groups is prevalent during embryogenesis, organ development, wound repair and tumour invasion. The mechanisms that underlie different forms of collective cell migration are not well understood, but some general principles are emerging.
Current Issue
Review
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Andrew J. Holland & Don W. Cleveland
The mitotic checkpoint is a cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Although aneuploidy is a common characteristic of tumours, it can suppress tumorigenesis in certain genetic contexts and cell types.
Current Issue
Research Highlights
Cell signalling:
An activating inhibitor?
Emily J. Chenette
A conformational change in AGC kinases enables them to be phosphorylated and activated in response to ATP-competitive inhibitors.
Cell signalling:
A fertility network
Simon Bishop
The role of the EGF signalling network in the luteinizing hormone-induced changes in ovarian follicular growth.
Advance Online Publication
Perspective
Growth, fluctuation and switching at microtubule plus ends
Jonathon Howard & Anthony A. Hyman
The growth of microtubules is accompanied by large fluctuations in rates and abrupt transitions between phases of growth and shrinkage. The authors propose that fluctuations in the length of the GTP–tubulin cap at the microtubule end could be the main source of variation.
Poster
Small RNA production
This Poster by V. Narry Kim and Mikiko C. Siomi depicts our current understanding of the processing pathways of eukaryotic small RNAs and their possible mechanisms of action, and accompanies their Review. The Poster is freely available thanks to support from Abcam.
Article series
Post-transcriptional control
The regulation of gene expression beyond the level of transcription is much more intricate than previously thought, and involves diverse mechanisms that regulate the processing, stability and localization of RNA species. In this new article series, we assess the basic mechanisms of post-transcriptional control and the interplay between them.
More Molecular Cell Biology
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Recommended Links
Links recommended by the Editors.
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Conferences
A calendar of forthcoming meetings and workshops from across the field of molecular and cell biology.
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Nature Milestones series
Collections of key discoveries that have shaped different scientific fields.
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molecular cell biology@nature.com
More articles on molecular cell biology from the Nature Publishing Group.
Noticeboard
Chromatin dynamics series
The articles in this new series focus on recent breakthroughs in our understanding of the mechanisms that govern the dynamic structural and spatial organization of chromatin in order to gain important insights into gene regulation, DNA repair, development and epigenetic inheritance.
Focus on Mechanotransduction
Cellular responses to mechanical forces drive morphogenesis and contribute to pathogenesis of diverse diseases. This special Focus reflects our current understanding of mechanotransduction — from how cells sense mechanical forces in different tissues to how these mechanical forces are transduced into biochemical signals — in development and disease.
Milestones in Cytoskeleton
Nature Milestones in Cytoskeleton focuses on the pivotal breakthroughs in cytoskeleton research over the past 60 years — from the discovery of actomyosin to the identification of molecular motors, and from fluorescence analogue cytochemistry and differential interference contrast microscopy to single–molecule in vitro assays.
Stem cells series
In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on the current hot and exciting topics in stem-cell research, discusses new technologies and resources to study stem cells and explores controversial issues, such as stem-cell ethics and funding.
Focus on Cell Polarity
Cell polarization is crucial for the development of unicellular and multicellular organisms and is achieved through the coordinated actions of signalling pathways, membrane trafficking mechanisms and cytoskeletal dynamics. This special Focus aims to capture the status quo of cell polarity research in a range of different systems by dissecting the underlying principles.
Poster on Pluripotent cell isolation for regenerative medicine
Pluripotent cells offer great promise for regenerative medicine. In this Poster, Christopher Lengner and Rudolf Jaenisch compare and contrast the properties of pluripotent embryonic stem cells with those of laboratory-generated pluripotent cells. The Poster is freely available thanks to support from STEMCELL Technologies Inc.
RNAi Gateway
From humble beginnings as an obscure phenomenon in plants, RNA interference (RNAi) has evolved into an area of significant impact in numerous fields. The newly launched RNAi Gateway provides a convenient portal into publications relevant to every aspect of RNAi from journals throughout the Nature Publishing Group.
Focus on Lipids
This Focus provides a snapshot of lipid biology. The accompanying Poster, which was produced with support from Merck Serono International S.A. provides an overview of the protein–lipid signalling network and how this network can be exploited to attenuate proliferative, inflammatory and metabolic diseases.
Poster on Readout of chromatin marks
This Poster illustrates well-known histone marks and representative examples of histone-binding effector modules, and outlines emerging themes in the molecular recognition of modified histones. It also describes possible modes of multivalent chromatin mark recognition, which are also discussed in the accompanying article by C. David Allis, Dinshaw J. Patel & colleagues.
Web Focus Collection
Please visit our archive of selected articles from the Nature Publishing Group on key current topics. Web Focuses are updated monthly with relevant Review and Perspective articles from Nature Reviews Molecular Cell Biology.
Journal Citation Reports, Thomson, 2009
