Nature Reviews Molecular Cell Biology
Volume 9, No 5 May 2008
Featured Article
Article series: Mechanisms of Disease
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri & Michael P. Czech
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2006 ISI Impact Factor 31.354(*Source of Impact Factor data)
Advance Online Publication
Review
Filopodia: molecular architecture and cellular functions
Pieta K. Mattila & Pekka Lappalainen
Filopodia are thin, actin-rich, finger-like structures that are involved in numerous cellular processes, such as cell migration, wound healing, neurite outgrowth and embryonic development. But what are the mechanisms that regulate filopodia formation in distinct cell types?
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Perspective
Membrane nanotubes: dynamic long-distance connections between animal cells
Daniel M. Davis & Stefanie Sowinski
Membrane nanotubes are thin extensions of the plasma membrane that connect cells transiently and might facilitate intercellular communication. Recent studies have revealed considerable heterogeneity in their structure, formation, mode of cargo transport and functional properties, depending on the cell types involved.
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Research Highlights
Cell signalling:
Dynamic redistribution
Ekat Kritikou
New findings highlight the diversity of mechanisms through which Wnt signals influence cells.
DNA repair:
Working on different ends
Francesca Cesari
The chemical nature of DNA break ends determines the pathway used to repair DNA.
Current Issue
Analysis
Transcriptional control of human p53-regulated genes
Todd Riley, Eduardo Sontag, Patricia Chen & Arnold Levine
The p53 protein regulates the transcription of many target genes in response to a wide variety of stress signals. This Analysis article presents the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
Current Issue
Review
Expansion and evolution of cell death programmes
Alexei Degterev & Junying Yuan
Cell death has historically been divided into regulated (apoptotic) and unregulated (necrotic) mechanisms. Emerging evidence, however, suggests that these two categories do not adequately explain all cell death mechanisms. How and why might non-apoptotic, regulated cell death mechanisms have evolved?
FOCUS ISSUE
Focus on Lipids
This Focus provides a snapshot of lipid biology. The accompanying Poster, which was produced with support from Merck Serono International S.A. provides an overview of the protein–lipid signalling network and how this network can be exploited to attenuate proliferative, inflammatory and metabolic diseases.
More Molecular Cell Biology
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Recommended Links
Links recommended by the Editors.
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Conferences
A calendar of forthcoming meetings and workshops from across the field of molecular and cell biology.
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Nature Milestones series
Collections of key discoveries that have shaped different scientific fields.
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molecular cell biology@nature.com
More articles on molecular cell biology from the Nature Publishing Group.
Noticeboard
Readout of chromatin marks
This Poster illustrates well-known histone marks and representative examples of histone-binding effector modules, and outlines emerging themes in the molecular recognition of modified histones. It also describes possible modes of multivalent chromatin mark recognition, which are also discussed in the accompanying article by C. David Allis, Dinshaw J. Patel and colleagues.
Focus on Ageing
This Focus highlights the latest advances in our understanding of ageing at the molecular and cellular level, and how this translates to organismal ageing. The accompanying podcast, which was produced with support from Sirtris Pharmaceuticals, features a round-table discussion with experts Lenny Guarente, Cynthia Kenyon and David Sinclair.
Stem cells series
In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on the current hot and exciting topics in stem-cell research, discusses new technologies and resources to study stem cells and explores controversial issues, such as stem-cell ethics and funding.
Mechanisms of disease series
A series of articles that reports on our current understanding of the molecular mechanisms that underlie a range of common human disorders, explores possible therapeutic targets and treatments, and discusses new technologies and resources to study disease mechanisms.
Web Focus Collection
Please visit our archive of selected articles from the Nature Publishing Group on key current topics. Web Focuses are updated monthly with relevant Review and Perspective articles from Nature Reviews Molecular Cell Biology.
Journal Citation Reports, Thomson, 2007