Collection |

Bioelectronic interfaces

This collection of papers from Nature Research and Reviews journals displays recent developments in materials science, electronics and biology of bioelectronic devices developed to communicate with different human tissues and organs. By showcasing new devices and approaches for engineering bioelectronic interfaces, it demonstrates the progress in understanding and designing electronic device-human interactions, specifically in the context of the cardiovascular system, nervous system, gastrointestinal tract, skin and musculoskeletal system.

The collection is curated by the Bioengineering and Biomaterials editorial community and published simultaneously to the beginning of the Nature Conference on 2D Flexible Electronics.

Nature Conference on Flexible Electronics - Visions of a Flexible Future
October 12-14, 2018
Jin Jiang International Hotel, Xi'an, China
This Nature conference on the theme of flexible electronics will set its sights firmly on the future, by exploring how flexible electronics will impact society by helping to tackle challenges in areas such as health, energy, ubiquitous electronics and the "Internet of Things".

Gastrointestinal tract

  • Nature Materials | Article

    A supramolecular elastic polymer that is stable in the acidic environment of the stomach but dissolves in the neutral-pH environment of the intestines is shown to function as a safe gastric-retentive device in pigs.

    • Shiyi Zhang
    • , Andrew M. Bellinger
    • , Dean L. Glettig
    • , Ross Barman
    • , Young-Ah Lucy Lee
    • , Jiahua Zhu
    • , Cody Cleveland
    • , Veronica A. Montgomery
    • , Li Gu
    • , Landon D. Nash
    • , Duncan J. Maitland
    • , Robert Langer
    •  &  Giovanni Traverso
  • Nature Communications | Article | open

    Current endoscopes are limited to detection or treatment of colon cancers and growths, or resolution is too low for clinical application. Here the authors present a multimodal endoscope with theranostic nanoparticles that integrates fluorescence-based mapping, electrical impedance, pH and temperature monitoring, RF ablation and localized phototherapy or chemotherapy.

    • Hyunjae Lee
    • , Youngsik Lee
    • , Changyeong Song
    • , Hye Rim Cho
    • , Roozbeh Ghaffari
    • , Tae Kyu Choi
    • , Kyung Hoon Kim
    • , Young Bum Lee
    • , Daishun Ling
    • , Hyuk Lee
    • , Su Jong Yu
    • , Seung Hong Choi
    • , Taeghwan Hyeon
    •  &  Dae-Hyeong Kim
  • Nature Biomedical Engineering | Article

    A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.

    • Phillip Nadeau
    • , Dina El-Damak
    • , Dean Glettig
    • , Yong Lin Kong
    • , Stacy Mo
    • , Cody Cleveland
    • , Lucas Booth
    • , Niclas Roxhed
    • , Robert Langer
    • , Anantha P. Chandrakasan
    •  &  Giovanni Traverso
  • Nature Reviews Materials | Comment

    Soft small robots offer the opportunity to non-invasively access human tissue to perform medical operations and deliver drugs; however, challenges in materials design, biocompatibility and function control remain to be overcome for soft robots to reach the clinic.

    • Metin Sitti
  • Nature Electronics | Article

    In a human pilot trial, ingestible electronic capsules, which can sense oxygen, hydrogen, and carbon dioxide gas in the gut, have been shown to be capable of monitoring changes in a person’s diet.

    • Kourosh Kalantar-Zadeh
    • , Kyle J. Berean
    • , Nam Ha
    • , Adam F. Chrimes
    • , Kai Xu
    • , Danilla Grando
    • , Jian Zhen Ou
    • , Naresh Pillai
    • , Jos L. Campbell
    • , Robert Brkljača
    • , Kirstin M. Taylor
    • , Rebecca E. Burgell
    • , Chu K. Yao
    • , Stephanie A. Ward
    • , Chris S. McSweeney
    • , Jane G. Muir
    •  &  Peter R. Gibson
  • Nature Biomedical Engineering | Article

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  &  Giovanni Traverso

Cardiovascular system

  • Nature Materials | Letter

    Heart-on-a-chip devices with integrated strain gauges for direct readout of tissue contractile strength allow for multiplexed drug-dose experiments and studies of functional maturation of cardiac tissue.

    • Johan U. Lind
    • , Travis A. Busbee
    • , Alexander D. Valentine
    • , Francesco S. Pasqualini
    • , Hongyan Yuan
    • , Moran Yadid
    • , Sung-Jin Park
    • , Arda Kotikian
    • , Alexander P. Nesmith
    • , Patrick H. Campbell
    • , Joost J. Vlassak
    • , Jennifer A. Lewis
    •  &  Kevin K. Parker
  • Nature Nanotechnology | Article

    A highly conductive, biocompatible and stretchable nanocomposite based on ultralong gold-coated silver nanowires allows for the realization of wearable and implantable bioelectronics.

    • Suji Choi
    • , Sang Ihn Han
    • , Dongjun Jung
    • , Hye Jin Hwang
    • , Chaehong Lim
    • , Soochan Bae
    • , Ok Kyu Park
    • , Cory M. Tschabrunn
    • , Mincheol Lee
    • , Sun Youn Bae
    • , Ji Woong Yu
    • , Ji Ho Ryu
    • , Sang-Woo Lee
    • , Kyungpyo Park
    • , Peter M. Kang
    • , Won Bo Lee
    • , Reza Nezafat
    • , Taeghwan Hyeon
    •  &  Dae-Hyeong Kim
  • Nature Biomedical Engineering | Article

    An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

    • Chonghe Wang
    • , Xiaoshi Li
    • , Hongjie Hu
    • , Lin Zhang
    • , Zhenlong Huang
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Zhenan Yin
    • , Brady Huang
    • , Hua Gong
    • , Shubha Bhaskaran
    • , Yue Gu
    • , Mitsutoshi Makihata
    • , Yuxuan Guo
    • , Yusheng Lei
    • , Yimu Chen
    • , Chunfeng Wang
    • , Yang Li
    • , Tianjiao Zhang
    • , Zeyu Chen
    • , Albert P. Pisano
    • , Liangfang Zhang
    • , Qifa Zhou
    •  &  Sheng Xu
  • Nature Reviews Cardiology | Review Article

    In this Review, Yacoub and McLeod summarize the rationale for monitoring patients with heart failure or pulmonary arterial hypertension to detect haemodynamic changes that predict the deterioration from subclinical to overt disease, the transition from noninvasive to implantable devices and the current and anticipated clinical use of these devices.

    • Magdi H. Yacoub
    •  &  Christopher McLeod

Skin and Musculoskeletal system

  • Nature | Letter

    By merging plastic-based skin sensors with silicon integrated circuits, a flexible, wearable perspiration analysis system is presented that measures skin temperature and the metabolites and electrolytes in human sweat and analyses the information in situ.

    • Wei Gao
    • , Sam Emaminejad
    • , Hnin Yin Yin Nyein
    • , Samyuktha Challa
    • , Kevin Chen
    • , Austin Peck
    • , Hossain M. Fahad
    • , Hiroki Ota
    • , Hiroshi Shiraki
    • , Daisuke Kiriya
    • , Der-Hsien Lien
    • , George A. Brooks
    • , Ronald W. Davis
    •  &  Ali Javey
  • Nature | Letter

    A scalable process is described for fabricating skin-like electronic circuitry that can be bent and stretched while retaining desirable electronic functionality.

    • Sihong Wang
    • , Jie Xu
    • , Weichen Wang
    • , Ging-Ji Nathan Wang
    • , Reza Rastak
    • , Francisco Molina-Lopez
    • , Jong Won Chung
    • , Simiao Niu
    • , Vivian R. Feig
    • , Jeffery Lopez
    • , Ting Lei
    • , Soon-Ki Kwon
    • , Yeongin Kim
    • , Amir M. Foudeh
    • , Anatol Ehrlich
    • , Andrea Gasperini
    • , Youngjun Yun
    • , Boris Murmann
    • , Jeffery B.-H. Tok
    •  &  Zhenan Bao
  • Nature | Letter

    Miniature hydrogel compartments in scalable stacked and folded geometries were used to prepare a contact-activated artificial electric organ.

    • Thomas B. H. Schroeder
    • , Anirvan Guha
    • , Aaron Lamoureux
    • , Gloria VanRenterghem
    • , David Sept
    • , Max Shtein
    • , Jerry Yang
    •  &  Michael Mayer
  • Nature Electronics | Review Article

    This Review Article examines the development of wearable sweat sensors, considering the challenges and opportunities for such technology in the context of personalized healthcare.

    • Mallika Bariya
    • , Hnin Yin Yin Nyein
    •  &  Ali Javey
  • Nature Electronics | Article

    Using carbon nanotube transistors, stretchable temperature sensor circuits can be designed that suppress strain-dependent errors and achieve a measured inaccuracy of only ±1 °C within a uniaxial strain range of 0–60%

    • Chenxin Zhu
    • , Alex Chortos
    • , Yue Wang
    • , Raphael Pfattner
    • , Ting Lei
    • , Allison Claire Hinckley
    • , Igor Pochorovski
    • , Xuzhou Yan
    • , John W.-F. To
    • , Jin Young Oh
    • , Jeffery B.-H. Tok
    • , Zhenan Bao
    •  &  Boris Murmann
  • Nature Electronics | Article

    Implantable pressure and strain sensors based on biodegradable materials have been designed to naturally decompose after their useful lifetime, eliminating the need for surgical extraction of the device.

    • Clementine M. Boutry
    • , Yukitoshi Kaizawa
    • , Bob C. Schroeder
    • , Alex Chortos
    • , Anaïs Legrand
    • , Zhen Wang
    • , James Chang
    • , Paige Fox
    •  &  Zhenan Bao

Nervous system

  • Nature | Letter

    New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents.

    • James J. Jun
    • , Nicholas A. Steinmetz
    • , Joshua H. Siegle
    • , Daniel J. Denman
    • , Marius Bauza
    • , Brian Barbarits
    • , Albert K. Lee
    • , Costas A. Anastassiou
    • , Alexandru Andrei
    • , Çağatay Aydın
    • , Mladen Barbic
    • , Timothy J. Blanche
    • , Vincent Bonin
    • , João Couto
    • , Barundeb Dutta
    • , Sergey L. Gratiy
    • , Diego A. Gutnisky
    • , Michael Häusser
    • , Bill Karsh
    • , Peter Ledochowitsch
    • , Carolina Mora Lopez
    • , Catalin Mitelut
    • , Silke Musa
    • , Michael Okun
    • , Marius Pachitariu
    • , Jan Putzeys
    • , P. Dylan Rich
    • , Cyrille Rossant
    • , Wei-lung Sun
    • , Karel Svoboda
    • , Matteo Carandini
    • , Kenneth D. Harris
    • , Christof Koch
    • , John O’Keefe
    •  &  Timothy D. Harris
  • Nature Nanotechnology | Article

    Rolled-up ultraflexible mesh electronics can be injected through a syringe needle of diameter as small as 100  μm into man-made and biological cavities, gels and tissues, where they can unfold and perform sensing operations.

    • Jia Liu
    • , Tian-Ming Fu
    • , Zengguang Cheng
    • , Guosong Hong
    • , Tao Zhou
    • , Lihua Jin
    • , Madhavi Duvvuri
    • , Zhe Jiang
    • , Peter Kruskal
    • , Chong Xie
    • , Zhigang Suo
    • , Ying Fang
    •  &  Charles M. Lieber
  • Nature Nanotechnology | Article

    A combination of planar porous electrodes, optoacoustic poration and laser scanning allows large-scale recording of intracellular action potentials of cardiomyocyte cultures on CMOS-MEAs.

    • Michele Dipalo
    • , Giovanni Melle
    • , Laura Lovato
    • , Andrea Jacassi
    • , Francesca Santoro
    • , Valeria Caprettini
    • , Andrea Schirato
    • , Alessandro Alabastri
    • , Denis Garoli
    • , Giulia Bruno
    • , Francesco Tantussi
    •  &  Francesco De Angelis
  • Nature Nanotechnology | Article

    The wireless and photoelectrochemical stimulation of primary rat dorsal root ganglion neurons is demonstrated by shining laser light onto coaxially doped silicon nanowires deposited on the neuronal membrane.

    • Ramya Parameswaran
    • , João L. Carvalho-de-Souza
    • , Yuanwen Jiang
    • , Michael J. Burke
    • , John F. Zimmerman
    • , Kelliann Koehler
    • , Andrew W. Phillips
    • , Jaeseok Yi
    • , Erin J. Adams
    • , Francisco Bezanilla
    •  &  Bozhi Tian
  • Nature Materials | Article

    Arrays of bioresorbable, highly doped silicon electrodes with multiplexing capabilities are used as electrocorticography sensors to perform in vivo, reliable acute and chronic recordings for up to one month before dissolving in the body.

    • Ki Jun Yu
    • , Duygu Kuzum
    • , Suk-Won Hwang
    • , Bong Hoon Kim
    • , Halvor Juul
    • , Nam Heon Kim
    • , Sang Min Won
    • , Ken Chiang
    • , Michael Trumpis
    • , Andrew G. Richardson
    • , Huanyu Cheng
    • , Hui Fang
    • , Marissa Thompson
    • , Hank Bink
    • , Delia Talos
    • , Kyung Jin Seo
    • , Hee Nam Lee
    • , Seung-Kyun Kang
    • , Jae-Hwan Kim
    • , Jung Yup Lee
    • , Younggang Huang
    • , Frances E. Jensen
    • , Marc A. Dichter
    • , Timothy H. Lucas
    • , Jonathan Viventi
    • , Brian Litt
    •  &  John A. Rogers
  • Nature Biotechnology | Article

    Cortical activity can be monitored for 6 months or longer from within the brain vasculature using an endovascular stent-electrode array.

    • Thomas J Oxley
    • , Nicholas L Opie
    • , Sam E John
    • , Gil S Rind
    • , Stephen M Ronayne
    • , Tracey L Wheeler
    • , Jack W Judy
    • , Alan J McDonald
    • , Anthony Dornom
    • , Timothy J H Lovell
    • , Christopher Steward
    • , David J Garrett
    • , Bradford A Moffat
    • , Elaine H Lui
    • , Nawaf Yassi
    • , Bruce C V Campbell
    • , Yan T Wong
    • , Kate E Fox
    • , Ewan S Nurse
    • , Iwan E Bennett
    • , Sébastien H Bauquier
    • , Kishan A Liyanage
    • , Nicole R van der Nagel
    • , Piero Perucca
    • , Arman Ahnood
    • , Katherine P Gill
    • , Bernard Yan
    • , Leonid Churilov
    • , Christopher R French
    • , Patricia M Desmond
    • , Malcolm K Horne
    • , Lynette Kiers
    • , Steven Prawer
    • , Stephen M Davis
    • , Anthony N Burkitt
    • , Peter J Mitchell
    • , David B Grayden
    • , Clive N May
    •  &  Terence J O'Brien