Collection 

Time-resolved structure determination

Submission status
Closed
Submission deadline

Time-resolved structure determination involves a range of techniques to capture and analyze the dynamic structural changes of molecules or materials over time. Methods include X-ray solution scattering and crystallography for the collection of rapid diffraction data during a (chemical) reaction or process; time-resolved spectroscopy for the monitoring of changes in light absorption, emission, or scattering; and ultrafast as well cryo electron microscopy for the capture of structural changes of proteins. Information about time-resolved structure has uses in fields as diverse as chemistry, materials science, and biology, and provide insights into reaction mechanisms, material behavior, and protein folding. New technology, much of it related to advances in computational hardware, is helping to improve time-resolved structure determination and contributing to research in these areas.

This Collection invites the submission of original research that either uses time-resolved structure determination as a main method of the study to address a research question or contributes to the development of methods used during ultra-fast structure determination.

Toll-like receptor 4 (TLR4, extracellular domain) bound to lipopolysaccharide (LPS) and MD-2. Involved in activating the innate immune system upon detecting LPS, a component of many gram-negative bacteria. 3D rendering based on protein data bank entry 3fxi. Combined cartoon and stick representation with backbone gradient coloring. Background black.

Editors

Magnus Andersson, PhD, Umeå University, Sweden

Magnus Andersson is an Associate Professor at the Department of Chemistry, Umeå University. His research focuses on tracking membrane protein dynamics in real time - primarily by synchrotron-based time-resolved X-ray solution scattering (TR-XSS). Of particular interest are the structural dynamics involved in regulatory processes of P-type ATPase transporters. Prof Andersson has been an Editorial Board Member for Scientific Reports since 2017.

 

 

Lan Guan, MD, PhD, Texas Tech University Health Sciences Center, USA

Lan Guan is a Professor at the Department of Cell Physiology and Molecular Biophysics and Co-Director of the Center for Membrane Protein Research at Texas Tech University Health Sciences Center, USA. Her laboratory focuses on 3-D structure, biochemistry, and integrated analysis, including CryoEM, X-ray crystallography, conformational nanobody, ligand binding, etc., to characterize the symport mechanisms of cation-coupled nutrient transporters. Prof Guan has been an Editorial Board Member for Scientific Reports since 2015.