Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.
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Acknowledgements
This work was supported in part by NIH grants R01AG076642 (M.X.), R01AG066679 (M.X.), U54AG079753 (M.X.), and R01AI173305 (J.M.B.).
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Bartley, J.M., Xu, M. Unleashing CAR T cells to delay metabolic aging. Nat Aging 4, 284–286 (2024). https://doi.org/10.1038/s43587-024-00576-5
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DOI: https://doi.org/10.1038/s43587-024-00576-5
